甲泼尼龙治疗重型肝炎前期31例  

Effect of Methylprednisolone on Prophase of Severe Hepatitis in 31 Cases

作　　者：严俊[1] 茹仁萍[1] 

机构地区：[1]浙江省杭州市第六人民医院,浙江杭州310014

出　　处：《中国药业》2008年第3期42-43,共2页China Pharmaceuticals

摘　　要：目的考察甲泼尼龙治疗重型肝炎前期的疗效。方法将61例患者分为治疗组及对照组,两组均进行护肝降酶和退黄治疗,对乙型肝炎病毒高复制者加用抗病毒治疗。治疗组在此基础上加用甲泼尼龙40～80mg静脉滴注(每8h一次),3d后改为口服泼尼松龙片40mg/d,据黄疸下降程度每隔5d减量5～10mg,直至停用。结果2周后总有效率治疗组为74.19%,对照组为46.66%,两组症状改善指标比较有非常显著性差异(P<0.01)。结论甲泼尼龙在重型肝炎前期治疗中能显著改善症状及肝功能,治疗总有效率高,但需严格掌握适应证。Objective To evaluate the effect of methylprednisolone on the prophase of severe hepatitis. Methods The patients were divided into two groups, including the control group and treatment group. Some treatments were performed with protecting liver, reducing enzyme and jaundice treatment. The high- copies HBV cases were managed with anti- virus treatment additionally. On the prophase of severe hepatitis, methylprednisolone 40-80 mg（q8h） was added in the treatment group and the prescription was changed to 40 mg/d after 3 d. After this, the dosage of prednisolone acetata was decreased 5 - 10 mg in treating intervals of 5 d based on the change of jaundice. Results There was a significant different between the two groups （P 〈 0. 01）. Conclusion Methylprednisolone is effective in the treatment of the prophase in severe hepatitis. But the use of this drug should be performed strictly keeping with the rule.

关 键 词：甲泼尼龙 重型肝炎前期 疗效 

分 类 号：R969.4[医药卫生—药理学] R977.11[医药卫生—药学]