类风湿性关节炎患者外周血IL-1RI水平的变化  

Relationship between interleukin-1 receptor I type in peripheral blood of rheumatoid arthritis patients

作　　者：黄宪章[1] 王前[1] 郑磊[1] 丁海明[2] 潘婉仪[2] 许羚雁[2] 庄俊华[2] 

机构地区：[1]南方医科大学南方医院检验医学中心 [2]广东省中医院二沙岛分院检验科,广州510105

出　　处：《广东医学》2008年第2期233-234,共2页Guangdong Medical Journal

基　　金：广东省科技计划项目(编号:2006B36003006);广东省自然科学基金资助项目(编号:07004832)

摘　　要：目的探讨外周血白细胞介素-1受体I型(IL-1RI)水平与类风湿性关节炎的相关性。方法应用酶联免疫吸附技术检测类风湿性关节炎(RA)患者94例,其中活动期和非活动期各47例;系统性红斑狼疮(SLE)患者40例,其中活动期和非活动期各20例;急性上呼吸道感染(AURTI)患者20例;健康体检者20名的外周血血清IL-1RI水平。结果各组间差异均有统计学意义(P<0.001)。RA组、SLE组、AURTI组和健康对照组均数间两两比较,RA组与各组间均有统计学意义(P<0.01),其余各组间差异均无统计学意义(P>0.05)。RA和SLE按临床症状分活动期和非活动期后各组均数间两两比较,RA活动期组与各组间差异均有统计学意义(P<0.05),RA非活动期与各组间差异均有统计学意义(P<0.05),其余各组间差异均无统计学意义(P>0.05)。结论外周血IL-1RI与类风湿性关节炎免疫炎症相关,可以作为RA的诊断和疗效判断指标之一。Objective To study the interleukin - 1 receptor I type （ IL - 1RI） level of peripheral blood of rheumatoid arthritis （RA） patients. Methods IL - 1RI was detected in 94 patients （47 active stage patients and 47 non - active stage patients） with rheumatoid arthritis, 40 patients （20 active stage patients and 20 non -active stage patients） with systemic lupus erythematosus （ SLE）, 20 acute upper respiratory tract infection patients （AURTI） and 20 healthy controls by using enzyme linked immuno - sorbent assay method. Results There were significant clifferenees in IL - 1RI level among all groups using ANOVA analysis （ P 〈 0. 001 ）. There was significant difference in IL - 1RI level between RA group and other groups （ P 〈 0. 001 ）, but there was no significant difference among other groups （ P 〉 0.05 ）. There was differ- enee in IL - 1RI level among active RA group, non - active RA group and other groups （P 〈0.05） , but there was no significant difference among other groups （ P 〉 0.05 ）. Conclusion IL - 1RI level in peripheral blood was associated with rheumatoid arthritis and may be used as maker for diagnosis and treatment of RA.

关 键 词：类风湿性关节炎 白细胞介素-1受体Ⅰ型 

分 类 号：R593.22[医药卫生—内科学]