PPAR-α与2型糖尿病  

PPAR-α and type 2 diabetes

作　　者：付秀立[1] 李竞[1] 

机构地区：[1]武汉大学人民医院内分泌科,430060

出　　处：《国际内分泌代谢杂志》2008年第1期45-47,52,共4页International Journal of Endocrinology and Metabolism

摘　　要：过氧化物酶体增殖物活化受体（PPAR）-α是配体依赖的核转录因子之一，在脂代谢中发挥关键作用。近年研究发现PPAR-α不仅通过改善胰岛素抵抗、调节胰岛素分泌量来调控血糖，而且在抑制炎性反应、加速脂质排泄、抑制平滑肌的增殖及游走等多阶段发挥抗动脉粥样硬化的作用，并能加速肾脏脂质的排泄，减少尿微量白蛋白的产生。PPAR-α激动剂可为预防及延缓2型糖尿病及其并发症提供新的方法。Peroxisome proliferators-activated receptor （PPAR）-α is one of the members of ligandactivated nuclear transcription factors, and plays a key role in the lipid metabolism. PPAR-α regulates glucose homeostasis through the amelioration of insulin resistance and insulin secretion. Meanwhile PPAR-α mediates its anti-atherosclerotic effects by exerting anti-inflammatory progression, stimulating cholesterol efflux and inhibiting the proliferation and migration of smooth muscular cells, and improves the renal protection by lipids excretion and reduction of albuminuria. PPAR-α agonists may be beneficial for the prevention or treatment of type 2 diabetes mellitus and its complications.

关 键 词：过氧化物酶体增殖物活化受体-α 2型糖尿病 动脉粥样硬化 糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]