尿白蛋白、视黄醇结合蛋白、转铁蛋白联合检测对糖尿病肾病早期诊断的意义  

Significance of Microalbumine,Retinol binding Protein Combine with Microtransferrin Excretion Rate in Early Diagnosis of Diabetic Nephropathy

作　　者：潘素芳[1] 朱良湘[1] 陈建文[1] 袁申元[1] 关宇舟 付汉菁[1] 胡虹莺[1] 武宝玉[1] 翟艳玲[1] 

机构地区：[1]北京同仁医院微循环糖尿病科

出　　处：《基础医学与临床》1997年第4期40-44,共5页Basic and Clinical Medicine

摘　　要：对４０例正常人测定２４小时尿白蛋白（Ａｌｂ）、视黄醇结合蛋白（ＲＢＰ）及转铁蛋白（ＴＲＦ），后两者９５％位数正常值为０．２２ｍｇ／２４ｈ、４．８８ｍｇ／２４ｈ。以上述三项指标共同测定４９例糖尿病患者２４ｈ尿，其中Ａｌｂ单项高于正常者２３例，占４６．９％，ＲＢＰ及ＴＲＦ单项高于正常者各２０例，各占４０．８％。若以三项联合检测中有一项异常即做为糖尿病肾病（ＤＮ）早期肾损伤，共有３１例，占６３．３％，其诊断ＤＮ阳性率明显高于单项异常者，Ｐ＜０．０５，且与合并糖尿病视网膜病变一致。可见，Ａｌｂ等糖尿病肾病早期诊断敏感指标的联合检测具有一定的临床意义。The 24 hour urinary microalbumine (Alb),urinary retinol binding protein (RBP) and urinary microtransferrin (TRF) in 40 healthy controls and 49 Diabetes Mellitus (DM) patients were determined simultaneously.The normal value of RBP and TRF were <0 22mg/24h and <4.88mg/24h respectively. In 49 DM patients,Alb increased in 46.9%,while both RBP and TRF increased in 40.8%.If the increase of any of the three index indicated early diagnosis of diabetic nephropathy,therefore the diagnostic positive rate increased to 63.3%,which was higher significantly than that the diagnosis based on single index positive (P<0.05) The diagnostic positive rate of diabetic nephropathy according to the urinary RBP,TRF and ALB was similar in the group of patients with diabetic retinopathy.

关 键 词：糖尿病 肾病 白蛋白 视黄醇结合蛋白 

分 类 号：R587.2[医药卫生—内分泌] R692.04[医药卫生—内科学]