庆大霉素聚氰基丙烯酸正丁酯毫微球在小鼠体内的分布  

BODY DISTRIBUTION OF GENTAMICIN POLYBUTYLCYANOACRYLATE NANOPARTICLES IN MICE

作　　者：张强[1] 廖工铁[2] 

机构地区：[1]北京医科大学药学院药剂教研室,100083 [2]华西医科大学

出　　处：《北京医科大学学报》1997年第4期339-340,365,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：了解庆大霉素毫微球的体内分布特征及主要影响因素。方法：采用同位素标记和液闪计数方法研究GM-NP在小鼠体内的分布。结果：GM与NP结合后，体内分布发生很大变化，肝、脾、肺中摄取增加，肌肉和血中分布下降；与溶液组相比，NP给药后放射性在体内下降更缓慢；亲水性表面活性剂可使网状内皮系统的分布减少。首次证实药物浓度也影响NP的体内分布。结论：本研究加深了对GM－NP体内行为的认识。Objective: To investigate the characteristics of the body distribution of gentamicin nanoparticles(GM-NP) and the major factors which affect the distribution. Methods: Body distribution of 3H labeledgentamicin polybutylcyanoacrylate nanoparticles in mice was studied by a liquid scintillation counter. Results:By comparsion with 3H labeled gentamicin solution (GM-Sol) the activity of GM-NP in liver, lung and spleen(RES) increased, while CPM in muscle and blood decreased. The activity of GM-NP driped more slowly thanthe GM-Sol group within 168 tested hours. The distribution of GM-NP in RES decreased after coating withsome hydrophlic surfectants and GM concentration also have some effect on the body distribution of GM-NP.Conclusion: A better understanding of in vivo behavior of GM-NP was achieved.

关 键 词：庆大霉素 药代动力学 胶体类 微球体 聚氰基 

分 类 号：R978.12[医药卫生—药品] R944.9[医药卫生—药学]