HIV-1感染患者中性粒细胞吞噬及细胞内杀菌功能的探讨  

STUDY OF PHAGOCYTOSIS AND INTRACELLULAR BACTERIOCIDE FUNCTION OF NEUTROPHILS IN PATIENTS WITH HIV-1 INFECTION

作　　者：李妤蓉 杨福江 

机构地区：[1]邢台医专检验教研室,邢台054000

出　　处：《现代预防医学》2008年第3期545-546,共2页Modern Preventive Medicine

摘　　要：[目的]探讨HIV/AIDS患者不同期中性粒细胞吞噬及细胞内杀菌功能的变化。[方法]采用普通酵母菌对13例患者及50例正常人进行中性粒细胞吞噬和细胞内杀菌功能试验,并与50名正常人比较。[结果]HIV-1感染患者中性粒细胞吞噬及细胞内杀菌功能明显低于正常人(P﹤0.01),艾滋病期和艾滋病前期的患者中粒细胞数明显低于正常人(P﹤0.01)。[结论]检测HIV-1感染患者中性粒细胞吞噬及细胞内杀菌功能和白细胞数变化对探讨AIDS患者易发生重复感染原因和疾病的治疗及预后有非常重要的价值。[Objective] To investigate phagocytosis and intraeellular sterilization funetion of neutrophils in patients with HIV-1 infeetion. [Methods] Yeast cells were used to examine phagoeytosis and intracellular baeterioeide function of neutrophils in 13 patients with HIV-1 infeetion and 50 subjects as eontrolsl [ Results] The phagoeytosis and intraeellular bacterioeide funetion of neutrophils in patients with HIV-1 infeetion were Considerably lowered than those in eontrols （P〈0.01）. [ Conclusion] Deteetion of phagoeytosis and intracellular sterilization funetion of neutrophils in patients with HIV-1 infection and the ehanged number of white blood cells may be Valuable to explore the reasons of happening superinfeetion faeilely, therapy and prognosis of AIDS patients.

关 键 词：HIV-1 吞噬细胞 中性粒细咆 

分 类 号：R512.91[医药卫生—内科学]