龙甲血脉通胶囊的抗心脏房室传导阻滞及活血化淤作用  

Effect of LO on anti-atrial ventricular block and promoting blood flow

作　　者：王玉姝[1] 孙尚见 周晓棉[1] 李欢[1] 王隽伟[1] 曹颖林[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]上海艾克药业有限公司,上海201400

出　　处：《沈阳药科大学学报》2008年第1期66-69,共4页Journal of Shenyang Pharmaceutical University

摘　　要：目的探讨龙甲血脉通胶囊(LO)抗心脏房室传导阻滞及活血化淤作用。方法采用盐酸维拉帕米诱导的家兔房室传导阻滞模型以及腺苷诱导豚鼠房室传导阻滞模型,考察LO抗心脏房室传导阻滞作用;采用ADP诱导的家兔血小板聚集试验和质量分数为10%的高分子右旋糖酐诱导大鼠血液流变学影响实验,考察LO的活血化淤作用。结果LO(0.80、0.40 g.kg-1)能够显著或者非常显著缩短盐酸维拉帕米诱导的家兔心电图PR间期、PP间期以及恢复正常心电图时间的延长(P<0.05,P<0.01),同时能显著缩短腺苷诱导豚鼠心电图PR间期的延长(P<0.05,P<0.01);能够降低ADP诱导的血小板聚集率(P<0.05,P<0.01),能够降低质量分数10%的高分子右旋糖酐诱导的大鼠高、中、低切血液黏度(P<0.05,P<0.01)。结论LO具有抗心脏房室传导阻滞和活血化淤作用。Objective To observe the effect of LO （traditional Chinese medicines） on anti-atrial ventricular block and promoting blood flow. Methods The atrial ventricular block model in rabbit induced by verapamil hydrochloride and the atrial ventricular block model of guinea pig induced by adenosine were used and the effect of LO on anti-atrial ventricular block was investigated. Moreover, the effect of LO on promoting blood flow was observed through the experiment of platelet aggregation of rabbit induced by ADP and the experiment of the rheol index of blood stasis rats induced by giant molecule dextran. Results At the doses of 0.80, 40 g·kg^-1, LO could depress the PR interval difference, PP interval difference and coincidence time（P〈0.05, P〈0.01）of the atrial ventricular block model of rabbit induced by verapamil hydrochloride, it could depress the PR interval difference of the atrial ventricular block model of guinea pig induced by adenosine（P 〈 0.05, P 〈 0.01） ;what is more, LO could depress the packing fraction of the platelet of rabbit, which was induced by ADP（P 〈 0.05, P 〈 0.01）, and depress the index of blood stasis rats induced by giant molecule dextran （P 〈 0.05, P 〈 0.01 ）. Conclusions LO has the effect of anti-atrial ventricular block and promoting blood flow.

关 键 词：房室传导阻滞 活血化淤 盐酸维拉帕米 腺苷 血小板聚集 高分子右旋糖酐 

分 类 号：R96[医药卫生—药理学]