硫氮酮对肾移植患者环孢素药动学和超氧化物歧化酶水平的影响  

THE EFFECT OF DILTIAZEM ON PHARMACOKINETICS OF CYCLOSPORINE AND SUPEROXIDE DISMUTASE LEVELS IN KIDNEY TRANSPLANT PATIENTS

作　　者：闫正华[1] 王茂义 董卫华[1] 

机构地区：[1]西安第一附属医院药剂科,西安710061

出　　处：《西安医科大学学报》1997年第2期223-225,共3页Journal of Xi'an Medical University(Chinese)

摘　　要：分别对4例及6例肾移植患者单用环孢素（CyclosporineCsA）与合用硫氮酮后CSA的药物动力学变化进行研究，并观察了其中9例患者血药浓度达峰时血浆超氧化物歧化酶（SOD）活性的变化。结果表明：肾移植患者CsA药动学参数个体差异大，合用硫氮酮后，CsA的β和T1／2α显著性降低，T1/2β显著性升高，峰浓度有一定升高，其它参数无明显改变（P>0．05）。合用硫氮酮后血浆SOD活性有一定增大。The changes of CsA,s pharma-cokinetics were studied in four kidney transplant pa-tients administered CsA and six patients adminis-tered CsA and Diltiazem. We observed the changes of SOD activity in nine patients when blood concen-tration of CsA getting peak. CsA concentrations were determined by FPIA. Pharmacokinetic param-eters were calculated by 3P87 program. The results indicated that CsA,s pharmacokinetics parameters of kidney transplant patients were greatly different when Diltiazem used. 9 and T1/.2a. of CsA descended evidently. T1/2β ascended remarkably. Peak concen-tration was ascendent. Other parameters had no changes. When using Diltiazem, SOD activity in serum had some changes.

关 键 词：环孢素 硫氮ZHUO酮 药物动力学 SOD 肾移植 

分 类 号：R699.2[医药卫生—泌尿科学]