Sec1/Munc18蛋白的研究进展  

Research Progress on Sec 1/Munc 18 Proteins

作　　者：董永明[1] 

机构地区：[1]华中科技大学生命科学与技术学院,武汉430074

出　　处：《现代生物医学进展》2008年第1期174-176,183,共4页Progress in Modern Biomedicine

基　　金：国家973基金(2004CB720000)

摘　　要：大多数细胞包含许多种转运到不同目的地的囊泡。尽管存在许多特定的转运途径,根本的分子原则非常相似并在进化中保守。有充足的证据表明,膜融合除需要SNARE蛋白家族的参与外,也需要Secl/Munc18(SM)蛋白;但是与SNARE蛋白功能的一致清楚相反,不同的实验系统得到的不同研究数据,使人们对于不同的SM蛋白的确切作用、作用位点和它们与SNARE蛋白的作用方式持不同观点。不同的SM蛋白与SNARE蛋白存在三种不同的作用模式。最近的研究确定,Munc18-1直接促进融合,并且它可能以所有三种模式与SNARE蛋白相互作用。本文综述了该领域的最新研究进展。Most cells contain a variety of transport vesicles traveling to different destinations. Although many specific transport routes exist, the basic molecular principles appear to be rather similar and conserved in evolution. Adequate evidence showed that membrane fusion needed the participation of Sec1/Munc18 （SM） proteins besides the SNARE protein family. But, contrary to the uniform clarity of SNARE proteins, different data on SM proteins were obtained in different experimental systems, resulting in researchers holding different views for exact effect and action site of SM proteins and its action mode with SNARE proteins. Different SM proteins and SNARE proteins have three kinds of different action modes, In recent researches,it has been determined that Munc18-1 directly promotes fusion and maybe interacts with SNARE proteins in all three modes. This paper reviewed the advancement of this domain.

关 键 词：Sec1/Munc18蛋白 膜融合 分泌 

分 类 号：Q189[生物学—神经生物学] Q813[生物学—普通生物学]