比格犬埃立克体病实验模型研究Ⅳ．盐酸多西环素治疗对血常规和血生化指标的影响  

Research on the Laboratory Model of Ehrlichiosis in Beagle Dogs Ⅳ. Effect on Blood Routine and Blood Biochemical Indexes after Treatment with Doxycycline Hyclate

作　　者：马玉海[1] 刘世忠[1] 刘广江[2] 曾昭智[3] 李洪涛[4] 吴清洪[4] 顾为望[4] 

机构地区：[1]广州军区疾病预防控制中心,广东广州510507 [2]广州市公安局巡警支队警犬队,广东广州510410 [3]广东药学院实验动物中心,广东广州510006 [4]南方医科大学实验动物中心,广东广州510515

出　　处：《动物医学进展》2008年第1期28-31,共4页Progress In Veterinary Medicine

基　　金：总后勤部面上课题(01MB035);广东省科技计划项目(2005B60302007)

摘　　要：为了观察盐酸多西环素对急性期犬埃立克体病的治疗效果,对人工感染埃立克体的比格犬进行了盐酸多西环素的治疗试验。采集比格犬感染前及治疗前后的血液样本,测定血常规及各项血生化指标,并对测定结果作统计学处理。血常规检测发现与治疗前相比,治疗后RBC、WBC、HGB、PLT、MPV、NEU-TRO、LYM、MONO和RDW显著升高;HCT、MCV、MCH和MCHC无明显变化;血生化检测发现,与治疗前相比,治疗后ALT和AST显著降低,ALB显著升高;治疗后与感染前相比,血常规和血生化各项均没有显著变化。进一步证实了盐酸多西环素对犬埃立克体病急性期病例具有良好的治疗效果。To study therapeutic efficacy of Doxycycline Hyclate, beagle dogs infected artificially with Ehrlichia Canis and E. platys were treated. Blood samples were obtained and analysed from 6 Beagle dogs before infection, after infection and after treatment. Comparing between before-treament and after-treatment, RBC, WBC, HGB, PLT, MPV, NEUTRO, LYM, MONO, RDW and ALB increased significantly, ALT and AST decreased significantly; comparing between before-infection and after-treatment, there were no significant changes in all blood routine and biochemical indexes. Our research confirmed that doxycycline hyclute can cure dogs with acute canine ehrlichiosis .

关 键 词：埃立克体病 盐酸多西环素 血常规 血生化指标 比格犬 

分 类 号：Q592.1[生物学—生物化学] S858.292[农业科学—临床兽医学]