志贺菌耐药性研究进展  

Advance in Drug Resistance of Shigella

作　　者：牛建荣[1] 张继瑜[1] 魏小娟[1] 王松泰[1] 李剑勇[1] 周绪正[1] 吴培星[1] 胡振英[1] 李金善[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,甘肃兰州730050

出　　处：《动物医学进展》2008年第1期73-76,共4页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(30671582)

摘　　要：概述了致病性志贺菌的分类,对家畜及人类造成的危害,临床多重耐药性严重状况。从分子生物学角度介绍了志贺菌主要耐药性acrAB-tolC主动外排系统的作用特点及耐药性相关药物外输蛋白marA、acrA、acrB,基因hdeA、tolB、tol A、tol Q等研究进展,并阐述了克服志贺菌耐药性的对策。This article reviewed the hazard to livestock and mankind caused by Shigella, the classification of Shigella and its state of muhidrug resistant in clinic,and also the feature of main drug resistance system acrAB-tolC and advance of drug resistance related gene. hdeA, tolB, tolA, tolQ, the medicamentous outside transport protein：marA,acrA,acrB etc. from molecular biology. The strategy of overcoming drug resistance of Shigella was expounded.

关 键 词：志贺菌 耐药性 acrAB—tolC主动外排系统 基因 外输送蛋白 

分 类 号：S852.612[农业科学—基础兽医学]