多组分中药化合物组释放/溶出动力学理论研究  

Novel Theory and Methods for Chemomic Multi-component Release/Dissolution Kinetics of Traditional Chinese Medicines

作　　者：张继稳[1] 陈立兵[2] 顾景凯[3] 葛卫红[2] 杨明[4] 

机构地区：[1]中国科学院上海药物研究所药物释放系统研究中心,上海201203 [2]浙江中医药大学药学院,杭州310053 [3]吉林大学药物代谢研究中心,长春130021 [4]江西中医学院现代中药制剂教育部重点实验室,南昌330006

出　　处：《中国天然药物》2008年第1期48-52,共5页

基　　金：国家高技术研究发展计划("863"计划)资助项目(No.2006AA02Z336);国家科技支撑计划项目(2006BAI098B08-08)~~

摘　　要：目的:建立以中药多组分整体为对象的化合物组释放/溶出动力学理论。方法:基于中药化合物组的整体谱特征,运用Kalman滤波法,计算获得溶出介质中化合物组含量,建立多组分中药的化合物组释放/溶出动力学评价理论;采用随机模拟数据,验证Kalman滤波法评价化合物组释放度的可行性,举例说明多组分中药化合物组释放/溶出动力学的计算方法。结果:示例表明,Kalman滤波法计算多组分化合物组浓度的线性、重现性、稳定性良好。结论:以Kalman滤波法为基础的多组分中药化合物组释放/溶出动力学理论与中医药的整体观相一致,具有可视化的直观、简化、定量结果,对优化设计多组分中药给药系统具有重要的方法学意义,其药动学、药效学意义有待进一步研究。AIM： To establish a novel theory for the release / dissolution kinetics of the traditional Chinese medicines （TCMs） with aims at multi-component chemome. METHODS： The theory and method for the release / dissolution kinetics of the TCMs were established based upon the overall spectrum of the chemome of the TCMs. The released chemomic levels of TCMs were processed by Kalman filter method with stochastic simulation data as an illustration of the methodology feasibility. RESULTS： Methodology study indicated that Kalman filter method was validated with good linearity, reproducibility, stability in calculation of the chemomic concentrations for the multi-component TCM release profile evaluation. CONCLUSION： Based on kalman filter method, the chemomic multi-component release / dissolution kinetics of TCMs is in line with the holistic theories of traditional Chinese medicine with illustrative visualization to simplify the massive results. The new theory shows methodological significance in optimal design of multi-component drug delivery systems of TCMs. The meaningfulness of the new method to pharmacokinetics and pharmacodynamics of TCM is to be clarified.

关 键 词：中药 化合物组 多组分 Kalman滤波法 释放度 溶出度 

分 类 号：R94[医药卫生—药剂学]