强心复脉颗粒对兔右冠状动脉缺血再灌注心律失常的干预作用  

Intervening Effect of Qiangxin Fumai Granule on Arrhythmia Induced by Right Coronary Artery Ischemi-a/Reperfusion in Rabbits

作　　者：谭双[1] 王彦云[2] 刘如秀[1] 万素君[2] 李多娇[2] 陈朝[2] 郑军[2] 

机构地区：[1]中国中医科学院广安门医院心内科,北京100053 [2]中国中医科学院广安门医院中药研发中心

出　　处：《中国中西医结合杂志》2008年第1期51-53,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家中医药管理局资助项目(No．04-05JP61)

摘　　要：目的观察兔右冠状动脉缺血再灌注(IR)致心律失常的演变及通阳活血中药强心复脉颗粒的干预作用。方法采用在体免右冠状动脉缺血再灌注模型,40只兔分5组:假手术组、模型组、阿托品组、强心复脉高、低剂量组,于缺血后10 min十二指肠给药1次。观察给药前后免的心房间期(AA间期)变化,计算心律失常评分。结果模型组兔缺血期AA间期延长40 ms以上,且随缺血时间延长,心律失常分数呈上升趋势,出现不同程度房室传导阻滞,窦性及房性心律失常加重;再灌注期房室传导阻滞发生次数减少,AA间期有所缩短。强心复脉高、低剂量组与模型组比较,AA间期明显缩短(P<0.01,P<0.05),心律失常评分显著降低(P<0.01,P<0.05)。结论通阳活血中药强心复脉颗粒具有缩短AA间期,对抗缺血再灌注所致心律失常的作用。Objective To observe the development of arrhythmia induced by ischemia/reperfusion （I/R） of the right coronary artery in rabbits and the intervening effect of Chinese medicine Qiangxin Fumai Granule （ QFG）, a Chinese preparation for activating yang and promoting blood circulation, on it. Methods Rabbit right coronary artery I/R model was adopted. Forty healthy adult rabbits were randomly divided into 5 groups, the sham-operation group, the model group, the atropine group, the high-dose QFG group, and the low-dose QFG group, eight in each group. The drugs were administered via duodenal perfusion 10 min after ischemia. The changes of AA interval before and after medication were observed and the scores of arrhythmia were calculated. Results During ischemia period, AA interval prolonged for more than 40 ms in the model group, and the scores of arrhythmia showed a rising trend along with the prolonging of ischemia, with the presence of atrial-ventricular block （AVB） and aggravating of sinus and atrial arrhythmia; during reperfusion period, the incidence of AVB decreased, and AA interval somewhat decreased. The AA intervals and scores of arrhythmia in the high and low-dose QFG groups were significantly lower than those in the model group respectively （ P 〈 0. 01 or P 〈 0. 05 ）. Conclusion QFG is beneficial for shortening AA interval and preventing arrhythmia induced by I/R.

关 键 词：缺血再灌注 强心复脉颗粒 心律失常 

分 类 号：R285.5[医药卫生—中药学]