正常人抽象图片记忆刺激的脑fMRI实验研究  

Functional MRI of brain in health volunteers during abstract pictures memory

作　　者：盛良驹[1] 姜平[2] 尉传社[3] 吴琴[4] 彭卫斌[1] 

机构地区：[1]江苏大学医学技术学院影像系,江苏镇江212001 [2]江苏大学医学院,江苏镇江212001 [3]江苏大学附属医院磁共振室,江苏镇江212001 [4]江苏大学电气学院,江苏镇江212001

出　　处：《中国临床解剖学杂志》2008年第1期49-51,共3页Chinese Journal of Clinical Anatomy

摘　　要：目的:运用功能磁共振成像(fMRI)研究志愿者抽象图片记忆提取时的脑内活动区情况及其年龄差异。方法:以3个年龄组共20名健康志愿者作为研究对象,运用单次激发GRE-EPI扫描采集fMRI图像,以抽象图片记忆的提取为刺激。用SPM软件对fMRI图像和T1W解剖图像进行融合,并对脑内活动区进行分析。结果:青年组正确率最高,儿童组次之,老年组最低。青年组在提取时在内侧颞叶有较强的激活区,而老年组内侧颞叶的激活强度较弱,但其它脑区的激活范围更广,儿童组则在内侧颞叶激活较弱,脑区的激活范围也不广。结论:脑记忆功能随着年龄而变化,在青年组,主导记忆功能的主要结构海马及其内侧颞叶功能最强;由于老年组的记忆力下降,其与记忆功能相关的结构功能减弱,但皮质及其它结构功能明显增强,儿童组则处在发育阶段。Objective： To study regional brain activation in the health volunteers and three age groups fi＇om abstract pictures memory. Methods： Single shot GRE-EPI imaging was performed individually in 20 health volunteers from three age groups during memory retrieval stimulation of abstract pictures, fMRI images were mixed and analysed with T1W anatomic images through software SPM. Brain activation regions were also analyzed. Results： Youth group is highest at the correct rate, children group is secondary, and aged group is lowest. Youth group has strong activity in medial temporal lobe （MTL） for retrieval stimulation, aged class has thinner activation in same areas but the range is more wider. Children group has neither strong activity nor wide activity areas. Conclusions： Functions of brain memory are changing with age. For the youth group, MTL and especially hippocampus which is dominating areas on memory-taking show strongest function; for the aged group, accompanied with weakening of memorial ability, activity of the structure correlated with memory descending, but cortex and other structure functions obviously increase. Children groups is in the phase of upgrowth.

关 键 词：功能磁共振成像 记忆 年龄 

分 类 号：R338.64[医药卫生—人体生理学]