酚妥拉明阻断去甲肾上腺素对大鼠束旁核痛反应神经元电活动的影响  

The effects of antagonizing norepinephrine by phentolamine on the activity of pain related neurons in pf in rats

作　　者：金秀东[1] 关艳中[1] 张书捷[1] 孙卫[1] 

机构地区：[1]牡丹江医学院生理学教研室,黑龙江牡丹江157011

出　　处：《中国临床解剖学杂志》2008年第1期91-94,共4页Chinese Journal of Clinical Anatomy

摘　　要：目的:去甲肾上腺素及其α受体阻断剂酚妥拉明对大鼠束旁核痛反应神经元电活动的影响。方法:以串刺激右侧坐骨神经为伤害性刺激,用玻璃微电极细胞外记录大鼠束旁核痛反应神经元电活动。结果:脑室去甲肾上腺素抑制旁核束旁核痛兴奋神经元放电,促进痛抑制神经元放电,此作用可被酚妥拉明阻断。结论:酚妥拉明阻断去甲肾上腺素对大鼠束旁核痛反应神经元电活动的抑制作用,提示去甲肾上腺素的镇痛作用与α肾上腺素能受体关系密切。Objecitve： to study antagonism of phentolamine on the effects of norepinephrine （NE） on the activity of pain related neurons in thalamus nucleus parafascicular（Pf） in rats. Methods： Using a chain of electric impuses to the right sciatic nerve as traumatic stimulus, and two glass microelectrodes in Pf to record the discharges of neurons by extracellular recording method, Results： （1） intracerebroventricular （i.c.v.） injection of norepinephrine resulted in the inhibition of electric changes of the pain-excitation neurons （PEN） and the excitation of the pain-inhibition neurons（PIN）; （2） The effects above can be antagonized by phentolamine ; （3） The electric changes of PEN and PIN in nucleus parafascicularis induced by norepinephrine were simultaneously antagonized by phentolamine. Clconclusion： The antagonism of the phentolamine on norepinephrine have inhibitory effects on the electric activity of pain related neurons in Pf in rats, which infer that pain-curbing effect of norepinephrine might be closely related with adrenergic α receptors.

关 键 词：酚妥拉明 去甲肾上腺素 大鼠 束旁核 痛反应神经元 

分 类 号：R542.2[医药卫生—心血管疾病]