ICAM-1/LFA-1在乳腺癌淋巴转移中表达的研究  

Expression of ICAM-1 and LFA-1 in Lymphatic Metastasis of Breast Cancer and its Clinical Significance at Present.

作　　者：何军[1] 杨树才[2] 张雅芳[2] 

机构地区：[1]黑龙江省齐齐哈尔医学院解剖教研室,161042 [2]哈尔滨医科大学解剖教研室

出　　处：《医学研究杂志》2008年第1期34-37,共4页Journal of Medical Research

摘　　要：目的通过观察人乳腺癌组织和癌旁"正常"乳腺组织中细胞间黏附分子-1(interce llular adhesion molecule-1,ICAM-1)和淋巴细胞功能相关抗原-1(lymphocyte function association antigen-1,LFA-1)的表达,探讨ICAM-1和LFA-1对乳腺癌淋巴道转移的影响。方法取乳腺癌60例和癌旁"正常"乳腺组织60例,用免疫组化的方法分别对上述两种组织中的ICAM-1和LFA-1表达进行观察,分析ICAM-1和LFA-1与乳腺癌淋巴道转移之间的关系。结果乳腺癌组织中ICAM-1、LFA-1表达的阳性率明显高于癌旁"正常"乳腺组织(P<0.01),在乳腺癌组织中,淋巴结转移阳性组中ICAM-1和LFA-1的表达明显高于淋巴结转移阴性组(P<0.05);乳腺癌组织中ICAM-1和LFA-1的表达具有正相关性(P>0.05)。结论ICAM-1和LFA-1与乳腺癌的淋巴道转移有关,并且通过两者的协同作用促进了乳腺癌的淋巴道转移,通过分析两者在乳腺癌组织中的表达,有助于评价肿瘤的转移能力,从而为乳腺癌淋巴道转移的预防和治疗起到一定的指导作用。Objective To explore the biological function of ICAM - 1and LFA - 1 in tumor metastasis, we observed the expression of ICAM - 1 （ Intercellular Adhension Molecule - 1 ） and LFA - 1 （ Lymphocyte function related antigen - 1 ） in cancer tissue and normal tissue. Methods A total of the samples were obtained from hospital, it includes 60 cases of breast cancer and 60 cases of normal mammary tissues. We observed the expression of ICAM - 1 and LFA - 1 by SP immunohistochemistry. We analyzed the relationship between the expression of ICAM - 1, LFA - 1 and lymphatic vessel metastasis of breast cancer. Results The expression positive rate of ICAM - 1and LFA - 1 in breast cancer was obviously higher than that in normal mammary tissues （P 〈0.01 ）. In breast cancer, the expression of ICAM - 1 and LFA - 1 in the group with lymph node metastasis, higher than that in the group without lymph node metastasis （P 〈 0.05 ）. The positive relativity of the expression was concluded between ICAM - 1 and LFA - 1 in breast cancer. Conclutions ICAM - 1 and LFA - 1 were related with breast cancer lymph metastasis and present synergism each other. It contribute to evaluate the competence of turnout metastasis, and have certainly instructive effect for the prevention and therapy of lymphatic vessel metastasis in breast cancer.

关 键 词：乳腺癌 细胞间黏附分子-1 淋巴细胞功能相关抗原-1 免疫组化 

分 类 号：R392.12[医药卫生—免疫学] R737.9[医药卫生—基础医学]