人用无佐剂狂犬病疫苗的接种反应及免疫效果  

Advese Reaction and Immune Effect Induced by Adjuvant-free Rabies Vaccine for Human Use

作　　者：肖奇友[1] 罗述斌[1] 李苗[1] 徐青松[1] 宋一平[1] 宋海晖[1] 张义[1] 钟群[1] 李谞[1] 徐葛林[2] 董关木[3] 

机构地区：[1]湖南省疾病预防控制中心,长沙410005 [2]武汉生物制品研究所基因工程室,武汉430060 [3]中国药品生物制品检定所疫苗一室,北京100050

出　　处：《中国生物制品学杂志》2008年第1期54-55,共2页Chinese Journal of Biologicals

基　　金：国家"十五"科技攻关资助项目(2004BA718B03)

摘　　要：目的观察人用无佐剂狂犬病疫苗的接种反应及免疫效果。方法使用无佐剂CTN-IV株Vero细胞疫苗和无佐剂AG株原代地鼠肾细胞疫苗免疫健康成人,按暴露后全程免疫程序接种,Vero细胞疫苗接种41人,地鼠肾细胞疫苗接种32人,观察其接种反应及免疫效果。结果接种人用无佐剂狂犬病疫苗后,无严重局部或全身不良反应出现。首剂免疫后14d,两组疫苗抗体阳转率均达100%,中和抗体滴度分别为7.29和6.35IU/ml,二者差异无显著意义。结论无佐剂狂犬病疫苗接种后无严重不良反应出现,且免疫效果良好。Objective To observe the advese reaction and immune effect induced by adjuvant-free rabies vaccine for human use. Methods Immunize healthy adults exposed to rabies virus with adjuvant-free rabies vaccine according the schedule for routine post-exposure immunization, of whom 41 with Vero cell-derived vaccine and 32 with hamster kidney cell-derived vaccine. Observe local and systemic adverse reactions within 72 h after immunization. Collect the serum samples on days 7 and 14 after the first dose for determination of neutralizing antibody by RFFIT. Results No severe local or systemic adverse reactions were observed after immunization. On day 14 after the first dose, both the antibody positive conversion rates of the subjects immunized with Vero cell-and hamster kidney cell-derived vaccine were 100%, and the neutralizing antibody titers were 7.29 and 6.35 IU/ml respectively. Conclusion Adjuvant-free rabies vaccine showed good immunogenicity.

关 键 词：狂犬病疫苗 佐剂 接种反应 免疫效果 

分 类 号：R392[医药卫生—免疫学] R512.99[医药卫生—基础医学]