参麦注射液对缺氧缺血性脑病新生儿血清白细胞介素-10、酸性钙结合蛋白-100β水平的影响  

Effect of Senmai Injection Therapy on the Level of Serum Interleukin-10,S-100β Protein in Newborn Infants with Hypoxic-Ischemic Encephalopathy

作　　者：王军[1] 蒋红侠 杨丽娟[1] 何艳芳[1] 周长美[1] 张绍美[1] 

机构地区：[1]徐州医学院附属医院新生儿科,江苏徐州221002 [2]徐州市中心医院儿科,江苏徐州221006

出　　处：《实用儿科临床杂志》2008年第2期148-149,共2页Journal of Applied Clinical Pediatrics

基　　金：江苏省卫生厅医学科技发展基金项目资助(z200308);徐州市科学技术项目资助(200310)

摘　　要：目的探讨参麦注射液(SMI)对缺氧缺血性脑病(HIE)新生儿的治疗作用及其机制。方法中重度HIE患儿45例。分为干预组20例,在综合治疗基础上,用SMI10mL/次加入100g/L葡萄糖溶液30～50mL静脉滴注;对照组25例仅综合治疗。二组均在给药后1、3、6d采集外周静脉血,放射免疫分析法检测其血清IL-10水平,酶联免疫分析法检测酸性钙结合蛋白(S-100β)水平。3月龄时门诊随访,进行神经精神运动发育商(DQ)测定。采用SPSS11.0软件进行组间t检验。结果与对照组比较,干预组治疗第1天,其血清IL-10、S-100β水平无显著性差异(t=0.33,0.77Pa>0.05);第3、6天其血清IL-10、S-100β水平明显低于对照组(t=5.34,2.92P<0.05,0.001)。3月龄时,二组患儿发育障碍发生率有明显差异(χ2=19.08P<0.05)。结论SMI可保护脑细胞改善预后,其机制可能与减轻炎性反应和阻断神经细胞损伤有关。Objective To explore the therapeutic effect of shenmai injection （SMI） on hypoxic - ischemic encephalopathy （HIE） neonates and its possible mechanism. Methods Forty - five newborn infants with moderate - severe HIE were divided into 2 groups： treatment group （n = 20）and control group（ n = 25 ）. The treatment group was given 10 mL SMI per day added into 30 -50 mL 100 g/L glucose and then injected into veins slowly combined with general treatment. The control group was orly received general treatment. Peripheral venous blood on 1, 3,6 d after treatment was collec-ted to measure the level of i nterleukin - 10 （IL - 10 ）and S - 10013 protein （S - 10013） in serum. The development quotient（DQ） of 2 groups was measured in the third months. Results Compared with the control group, the levels of IL- 10 and S - 10013 in serum of the treated group were obviously lower than those in the control group on 3,6 d after being treated （ t = 5.34,2.92,6.40, 7.79 0.77 P 〈 0.05,0. 001 ）. There was significant difference in the DQ between treatment group and control group （ Х^2 = 19.08 P 〈 0.05）. Conclusions SMI has a significant protective effect on HIE, it may be associated with the decrease of inflammatory response and block the damage of nervous ceils.

关 键 词：缺氧缺血 脑 参麦注射液 婴儿 新生 白细胞介素-10 酸性钙结合蛋白-100β 

分 类 号：R722.1[医药卫生—儿科]