单唾液酸四己糖神经节苷脂早期治疗中重度缺氧缺血性脑病新生儿的疗效  

Curative Effects of Monosialotetrahexosyl Ganglioside on Neonates with Moderate and Severe Hypoxic-Ischemic Encephalopathy

作　　者：陆亚东[1] 李勇[1] 周晓玉[1] 贲晓明[1] 

机构地区：[1]南京医科大学附属南京儿童医院新生儿科,南京210008

出　　处：《实用儿科临床杂志》2008年第2期150-151,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的观察单唾液酸四己糖神经节苷脂(GM1)治疗中重度缺氧缺血性脑病(HIE)新生儿的疗效。方法中重度HIE新生儿86例随机分为2组:常规治疗组(对照组)42例;GM1干预组44例。二组患儿均予常规治疗。干预组在常规治疗的基础上早期(生后6h内)应用GM1(20mg)静脉滴注治疗。1次/d,10～14d为1个疗程。治疗前治疗1个疗程和28d检查2组头颅CT、行为神经评分(NBNA),12个月时采用首都儿科研究所儿心量表(CDCC)评定智力/运动发育指数。采用StatisticView5.0软件进行t检验和χ2检验。结果GM1干预组头颅CT影像学脑结构的恢复及NBNA评分均明显优于对照组(Pa<0.05),MDI、PDI等各项指标与对照组比较均有明显改善(P<0.01)。结论早期应用GM1治疗中重度HIE有明显疗效。Objective To observe the curative effects of monosialotetrabexosyl ganglioside （GM1） on neonates with moderate and severe hypoxic- ischemic encephalopathy（HIE）. Methods Eighty- six neonates with HIE were randomly divided into GM1 treatment group and control group. The control group （42 cases）were received routine treatment （including cerebrolysin and citicoline） ;the treatment group （44 cases ） were given GM1 on the basis of routine treatment as early as possible （within 6 hours after birth）. Brain CT,neonatal behavioral neurological assessment （NBNA）and children＇s development center of China （CDCC） at 12 months after birth were proformed in both groups. Restilts Brain CT , NBNA and CDCC markers in treatment group were better than those in control group （ Pa 〈 0.05 ）. There were great differences between two groups （ Pa 〈 0.05 ）. Conclusions Using GM1 on the basis of the routine treatment as early as possible after resuscitation can reduce markedly the severity of asphyxia - induced brain damage in neonates. It is very effective using GM1 in treating HIE in neonates.

关 键 词：缺氧缺血 脑 神经节苷脂 婴儿 新生 

分 类 号：R722.1[医药卫生—儿科]