急性心肌梗死患者血浆B型利钠肽与短期心力衰竭的临床关系  

Relations of BNP and short-term heart failure in acute myocardial infarction

作　　者：田玮[1] 付研[1] 

机构地区：[1]首都医科大学附属北京同仁医院急诊科,北京100730

出　　处：《山西医科大学学报》2008年第1期46-48,共3页Journal of Shanxi Medical University

摘　　要：目的研究急性心肌梗死患者血浆B型利钠肽(BNP)的浓度与短期心力衰竭的临床关系。方法111名急性心肌梗死患者分为灌注治疗组和非灌注治疗组,测定入院时和入院后第7天的血浆BNP浓度及超声心动检查,所有患者自入院起随访30d。结果两组患者在入院时血浆BNP水平均增高,但各组间比较无统计学差异(P>0.05)。入院第7d,灌注组血浆BNP水平较入院时显著降低(P<0.01),而非灌注组前壁心梗患者血浆BNP水平反而较入院时增高,两者有统计学差异(P<0.05)。灌注组超声心动检查中左室射血分数(LVEF)与左室舒张末径(LVEDD)优于非灌注组。第7天BNP浓度与第7天的超声心动检查中的LVEF呈负相关(r=-0.393,P<0.05),与LVEDD呈显著的正相关(r=0.425,P<0.01)。入院时及第7天血浆BNP浓度与心梗后近期心衰的发生明显相关(P<0.01)。结论血浆BNP浓度是心肌梗死后发生早期心力衰竭的预测因子。Objective To investigate the relations between BNP level and short-term heart failure in AMI patients. Methods One hundred and eleven patients with acute myocardial infarction were divided into two groups： perfusion group and non-perfusion group. The rapid plasma BNP levels were measured in all patients before treatment and at 7 d after treatment. All patients were followed up after admission for 30 d. Results In two groups, BNP levels increased immediately at admission, but there was no significant difference between them. At 7 d after admission, BNP levels in perfusion group significantly decreased （P 〈 0.05）, but BNP levels of anterior AMI increased significantly in non-perfusion group （P〈0.05）. UCG showed that LVEF and LVEDD in perfusion group were better than in non-perfusion group at 7 d after admission. At 7 d after admission, BNP level was negatively correlated to LVEF （ r = 0. 393, P 〈 0.01 ）, but positively correlated with LVEDD （ r = 0. 425, P 〈 0.01 ）. BNP levels at admission and at 7 d were markedly correlated to the occurrence of heart failure events（P 〈 0.01）. Conclusion The plasma BNP levels could be a predictor for occurrence of heart failure in AMI patients.

关 键 词：心肌梗死 B型利钠肽 预后 

分 类 号：R542.22[医药卫生—心血管疾病]