速度向量成像结合心肌超声造影评价犬急性心肌缺血局部心肌功能  

Assessment of regional myocardial function in dogs with acute myocardial ischemia using velocity vector imaging combined with myocardial contrast echocardiography

作　　者：宋军[1] 杨海山[1] 孟令均[1] 吴敦茁[1] 任双丽[1] 张俊倩 周瑞刚 高东梅[1] 

机构地区：[1]吉林大学中日联谊医院,吉林长春130031 [2]东辽县第三人民医院 [3]长白县医院

出　　处：《中国实验诊断学》2008年第1期22-25,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨速度向量成像技术评价急性心肌缺血后左心室局部心肌收缩功能改变的价值。方法健康杂种犬10只,开胸并于第一对角支1 cm以下套扎左冠状动脉前降支,分别在套扎前基础组、套扎30分钟后缺血组,用超声心动图速度向量成像技术记录左室局部心肌收缩期峰值速度(VSYS),峰值应变(SSYS)、峰值应变率(SRSYS),用声诺维进行实时心肌超声造影(MCE),对局部室壁心肌造影强度-时间曲线进行指数方程Y=A.(1-exp-k.t)拟合。结果与基础组比较缺血节段心肌血流灌注异常,标化后的A.K值明显减低(P<0.05),长轴方向上收缩期VSYS、SSYS、SRSYS均明显减低(P<0.001)。结论长轴方向上收缩期峰值速度,应变、应变率能够准确、敏感地发现急性心肌缺血导致的局部心肌收缩功能障碍。Objective To explore the value of velocity vector imaging（VVI） in assessing left ventrieuiar regional myocardial systolic functions in dogs with acute myocardial ischemia.Methods ten dogs,RT-MCE with Contrast media and VVI were performed at baseline and 30 minutes after occlude left anterior descending coronary arteries（LAD） respectively. The regional myocardial contrast intensity versus refilling tinle plots were fitted to an exponential function：y = A· （1-exp^-k·t） ＋ B,the product ofA and βrepresented myocardial blood flow. using VVI measure the VSYS,S SYS, SRSYS. Results RT-MCE showed that normalized A· k in the regional myocardial of acute ischemia decreased severely（ P 〈 0.05）. The peak systolic velocities and stain, strain rate recorded by VVI dechned significantly（ P 〈 0.001）. Conclusion Longitudinal peak systolic velocity, stain, strain rate are accurate and sensitive indices for detection myocardial ischemia.

关 键 词：超声检查 造影剂 心肌缺血 左室功能 速度向量成像 

分 类 号：R445.1[医药卫生—影像医学与核医学]