日本血吸虫尾蚴与烷烯炔烃衍生物的亲和性  

Study on difreriental affinity between schistosoma cercaria and alkane olefm alkyne derivative

作　　者：高艳春[1] 范玉兰[1] 郭维[1] 李勋[1] 李小康[1] 范小林[1] 

机构地区：[1]江西赣州赣南师范学院化学与生命科学学院,江西省有机药物化学重点实验室,341000

出　　处：《中国地方病学杂志》2008年第1期53-55,共3页Chinese Jouranl of Endemiology

基　　金：国家自然科学基金（50478117、50568001）

摘　　要：目的观察日本血吸虫尾蚴与烷烃、烯烃、炔烃系列衍生物的亲和特性。方法将月桂酸、巴豆酸、亚油酸、亚麻酸、油酸等25种化合物，通过溶液涂膜的方法，将其附着在载玻片上，采用生物彩色电视显微镜对日本血吸虫尾蚴活体在不同化合物涂片上的黏附情况进行实时观测。结果正辛酸和亚油酸对日本血吸虫尾蚴绝对获蚴率较好，分别为52．2％、59．4％。结论正辛酸和亚油酸对日本血吸虫尾蚴具有较好的特异亲和性。Objective To study the differiental affinity between schistosoma cercaria and alkane olefin alkyne derivatives. Methods 25 compounds including lauric acid,crotonic acid, linoleic acid, linolenic acid, oleicacid and so on were smeared on the slice. The real-time adherency to schistosoma cercarie on different slices was observed with biological color television microscope. Results The n-caprylic acid and linoleic acid had a better absolute capture ratio of cercarie, being 52.2% and 59.4% separately. Conclusions The n-caprylic acid and linoleic acid have a better specific affinity to schistosoma cercaria.

关 键 词：血吸虫 日本 烷烃类 烯烃类 炔类 

分 类 号：R686[医药卫生—骨科学]