健康志愿者临床试验前后的焦虑与抑郁水平  

Level of anxiety and depression on volunteers in clinic trial

作　　者：蒋珍妮[1] 朱莹[1] 莫亚莉[2] 单江[1] 

机构地区：[1]浙江大学医学院附属第二医院心内科,浙江杭州310009 [2]杭州市第七医院精神科,浙江杭州310013

出　　处：《中国病理生理杂志》2008年第1期51-53,共3页Chinese Journal of Pathophysiology

摘　　要：目的:评估健康志愿者临床试验前后的焦虑与抑郁水平,探讨产生焦虑与抑郁情绪的影响因素及积极应对方式。方法:对35例健康志愿者进行焦虑自评量表(SAS)、抑郁自评量表(SDS)和艾森克个性问卷(EPQ)测定。结果:(1)健康志愿者参加临床试验前SAS标准分为35.40±9.64,与常模组33.80±5.80相比有升高趋势,但无显著差异,P>0.05;与试验后30.94±6.15比较,P<0.05,有显著差异。(2)试验前后SDS标准分别为35.17±6.93、34.91±6.74;P>0.05,无显著差异;均低于常模组。(3)健康志愿者人格特征与焦虑和抑郁情绪之间具有相关性:艾森克个性问卷(EPQ)量表中的N、P得分与SAS、SDS均有显著性相关,r=0.338/0.608和0.335/0.455(P<0.05);而E分与SAS、SDS得分相关不明显。人格特质是影响焦虑水平的重要因素。结论:健康志愿者在接受临床试验前后会产生焦虑情绪,个性特征与精神状态密切相关。AIM ： To assess the mental health level of anxiety and depression and related factors in healthy volunteers in clinic trial. METHODS： Self- rating anxiety scale （ SAS）, self - rating depressive scale （SDS） and Eysenck personality question （EPQ） were applied to thirty -five patients. RESULTS： Among the 35 patients, the SAS standard mean value was 35.40 ± 9. 64, which was higher than that of nation - norm （ P 〉 0. 05 ）, and significantly higher than that of volunteers after trials （P 〈0. 05）. The SDS standard mean value was 35. 17±6.93 beforetrials and 34. 91±6. 93 after trials, which was lower than that of nation - norm. As compared with nation - norm, EPQ scores of intro - and extro - version were significantly lower, and neuroticism and psycho were all significantly higher （P 〈0. 05, P 〈0. 01 ）. It showed that the standard mean values of SAS and SDS before trials were positively related to EPQ P and N score. CONCLUSION ： Mental problems existed in healthy volunteers on clinic trials and the occurrence of mental problems are related to their personality characteristic and sociological factors.

关 键 词：健康志愿者 焦虑 抑郁症 问卷 艾森克人格问卷 

分 类 号：R969[医药卫生—药理学]