原始卵泡形成与早期卵泡发育的遗传调控  

Genetic Regulation of the Primordial Follicle Formation and Earliest Follicular Development

作　　者：孙理兰[1] 谷朝勇[2] 潘庆杰[1] 沈伟[1] 

机构地区：[1]青岛农业大学动物科技学院动物生殖发育与基因工程研究所,山东青岛266109 [2]菏泽学院,山东菏泽274000

出　　处：《生物技术通讯》2008年第1期120-124,共5页Letters in Biotechnology

基　　金：国家重点基础研究发展规划项目(2007CB947401);国家自然科学基金项目(30700422);山东省自然科学基金项目(Z2007D01);青岛市科技计划项目(06-2-2-11-jch);青岛农业大学博士基金重点项目(630615)

摘　　要：原始卵泡形成与早期发育调控对卵母细胞发育来说非常重要,通过对原始卵泡的体外培养,可以了解原始卵泡发育的调节机制。原始卵泡向初级卵泡的转变不依赖于促性腺激素,而主要受卵巢旁分泌因子的调控,包括Kit/KL、GDF9等促进因子和AMH等抑制因子的调控。目前,原始卵泡发育的分子调控机理研究多以小鼠为模型,而对大型哺乳动物和人的研究甚少。概述了哺乳动物原始卵泡形成与发育启动调控机制的既有研究成果,详细阐述了原始卵泡发育过程中关键分子的调控作用,并介绍了小鼠及其他哺乳动物卵泡体外培养的研究进展。The regulatory of primordial follicle formation and earliest follicular development are important for mammalia oogenesis. Culture of primordial follicle in vitro was used to understand the regulatory mechanism of primordial follicle de velopment. The transition from primordial to primary follicle is gonadotropin-independent, but regulated ＂mainly by intraoval ian factors, including Kit/KL, GDF9, KGF, NOBOX, AMH and so on. The study on regulatory mechanism of the primol dial follicle formation and earliest follicular development is in mouse model mostly, but in large mammals and human, only some aspects of follicle development have been studied because of the limited availability of suitable material for experimentation. In this review, recent research achievement on the regulatory mechanism of initiation of the primordial folli cle development in mammals was reviewed, and the regulation of key factors on primordial follicle development was ex pounded, and study progress in mouse and other mammals in vitro culture was introduced.

关 键 词：原始卵泡 卵泡发育 卵母细胞发生 分子调控 

分 类 号：Q25[生物学—细胞生物学]