哺乳动物卵母细胞异位发育技术及其研究进展  

Ectopic Development Technology of Mammalian Oocytes

作　　者：翟向玮[1] 谷朝勇[2] 潘庆杰[1] 沈伟[1] 

机构地区：[1]青岛农业大学动物科技学院动物生殖发育与基因工程研究所,山东青岛266109 [2]菏泽学院,山东菏泽274000

出　　处：《生物技术通讯》2008年第1期125-129,共5页Letters in Biotechnology

基　　金：国家重点基础研究发展规划项目(2007CB947401);国家自然科学基金项目(30700422);山东省自然科学基金项目(Z2007D01);青岛市科技计划项目(06-2-2-11-jch);青岛农业大学博士基金重点项目(630615)

摘　　要：综述了哺乳动物卵巢移植在生物医学上的应用,及借助卵巢异位发育研究卵巢卵母细胞发育机制的研究进展;详细介绍了卵巢移植的不同技术方法,及移植后卵巢卵母细胞的发育、激素的调节机制,分析了卵巢移植早期卵泡生长和凋亡的分子机理及其在移植医学中的应用前景,并就新鲜和冻融卵巢如何用于动物辅助生殖进行了阐述。特别关注卵巢卵母细胞异种移植的潜在价值,卵巢异种移植不仅可以保存稀有和濒危物种,还可以为当前辅助生殖技术提供一个理想的实验手段。The application of mammal ovary transplantation on biomedicine was reviewed. The ovary transplantation was used as a tool to investigate ovarian function, and the development of ovary oocytes and regulatory mechanism of hormones after transplantation were introducted in detail. Molecular mechanisms of follicle growth and apoptosis in early ovary transplantation and perspective in transplantation medicine were analyzed, with account for how fresh and frozen ovarian tissue can be used in assisted reproduction for animals. This paper focused most closely on the potential value of xenotransplantation in ovary oocytes. The technology of ovary xenotransplantation can be used to conserve rare and endangered animal species, also to provide a ideal experimental means for current assisted reproductive technologies.

关 键 词：卵子发生 卵泡发育 卵巢 异位发育 

分 类 号：Q25[生物学—细胞生物学]