腹腔液及异位内膜组织MCP-1、IGF-Ⅰ水平变化与子宫内膜异位症发病及不孕的相关性分析  

The correlation between the changes of levels of MCP-1and IGF-Ⅰin peritoneal fluid and pathogenesis of endometriosis and infertility

作　　者：卢丽萍[1] 卢杰平[2] 潘莉莉[1] 李强[1] 

机构地区：[1]中国医科大学附属盛京医院,沈阳110004 [2]沈阳市苏家屯区妇婴医院妇产科,沈阳110101

出　　处：《中国优生与遗传杂志》2008年第2期59-61,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨子宫内膜异位症(Endometriosis,EM)患者腹腔液、异位内膜组织中单核细胞趋化蛋白-1(mon-ocyte chemotactic protein-1,MCP-1)、胰岛素样生长因子-I(Insulin-like growth factors-I,IGF-I)的变化在子宫内膜异位症发病及不孕中的作用。方法EM患者30例作为观察组,其中早期病例(Ⅰ-Ⅱ期)10例,晚期病例(Ⅲ-Ⅳ)20例;合并不孕症患者12例,非不孕症者18例。10例无内膜异位症者作为对照组。用酶联免疫检测(ELISA)方法测定两组腹腔液、内膜组织中的MCP-1、IGF-Ⅰ含量的变化。结果(1)内膜异位症组腹腔液、异位内膜组织中MCP-1、IGF-Ⅰ水平与对照组相比较有显著差异(P<0.01),且早期病例腹腔液MCP-1、IGF-Ⅰ水平及内膜组织MCP-1水平均明显高于晚期病例,差异显著(P<0.05)。(2)内异症合并不孕症患者腹腔液IGF-Ⅰ水平与非不孕症比较有显著差异(P<0.05)。结论内膜异位症患者腹腔液中MCP-1、IGF-Ⅰ的变化在子宫内膜异位症发病机制中具有一定作用。Objective： The aim of the study was to investigate the role of monocyte chemotactic protein -1 （ MCP - 1 ） and Insulin- like growth factors -Ⅰ （IGF-Ⅰ） in the endometriosis pathogenesis and infertile. Methods： Peritoneal fluid and ectopic endometrial tissues of 30 patients with endometriosis （10 early stage and 20 severe stage; 12 with infertility and 18 without infertility） and 10 no - endometriosis were obtained . The ELISA was employed to measured MCP - 1 and IGF -Ⅰ levels. Results： （ 1 ） The levels of MCP- 1and IGF -Ⅰ in the peritoneal fluid and ectopic endometrial tissues were significantly elevated in EM group as compared with those in control group （10cases） （ P 〈0.01） ; especially the levels of MCP-land IGF -Ⅰ of the peritoneal fluid and MCP - 1 level of ectopic endometrial tissues were significantly higher in early stages than those in severe stages （ P 〈0.05 ）. （2） The level of peritoneal fluid IGF -Ⅰ was found to be significantly higher in patients with infertility than those of without infertility （ P〈0.05 ）. Conclusion ： Our results indicated that the changes of MCP -1 and IGF-Ⅰ may play some roles in the pathogenesis of endometriotic lesions.

关 键 词：子宫内膜异住症 胰岛素样生长因子 单核细胞趋化蛋白-1 腹腔液 异位内膜组织 

分 类 号：R711.71[医药卫生—妇产科学] R711.6[医药卫生—临床医学]