2型糖尿病心血瘀证模型大鼠血脂、血液流变学、微循环的变化  

Changes of Blood Lipid,Blood Rheology and Microcirculation of Model Rats of Diabetes Ⅱ with Heart Blood Stasis Syndrome

作　　者：谢梦洲[1] 田浩梅[1] 陈楚淘[1] 莫楠[1] 李露丹[1] 何军锋[1] 喻道贵[1] 

机构地区：[1]湖南中医药大学中医诊断研究所,长沙市韶山中路113号410007

出　　处：《中医杂志》2007年第12期1119-1121,共3页Journal of Traditional Chinese Medicine

基　　金：湖南省教育厅课题(05C383)

摘　　要：目的探讨2型糖尿病心血瘀证模型大鼠的血脂、血液流变学、球结膜微循环之间的关系。方法采用高脂高热量饲料喂养并结合小剂量链脲佐菌素(STZ)腹腔注射的方法制备2型糖尿病大鼠模型的基础上,再行地塞米松和肾上腺素腹腔注射制备2型糖尿病心血瘀证大鼠模型。空腹8小时后麻醉大鼠,测球结膜微循环、颈动脉取血测血脂、血液流变学。结果该模型鼠血脂、血液流变学和球结膜微循环指标均出现异常,符合糖尿病心血管并发症的变化规律。Objective To explore the relations among blood lipid, blood rheology and microcirculation of bulbar conjunctiva of model rats of diabetes Ⅱ with heart blood stasis syndrome. Methods The rats were fed with high fat and caloric feed. Intraperitoneal injection of streptozotocin （STZ） in small dosage was applied to make the model of diabetes Ⅱ . Then the model of heart blood stasis syndrome was made through introperitoneal injecting dexamethasone and adrenalin. Eight hours after empty stomach, the rats were anaesthetized to measure the microcirculation of bulbar conjunctiva and test the blood lipid and carotid blood rheology. Results The indices of blood lipid, blood rheology and bulbar conjunctiva microcirculation of model rats were all changed to abnormal, tallying with the changes of cardiovascular complications of diabetes.

关 键 词：2型糖尿病心血瘀证 模型大鼠 血脂 血液流变学 微循环 

分 类 号：R259[医药卫生—中西医结合]