玻璃酸钠预防开腹术后腹腔粘连的实验研究  

Experimental Study of Effect of Sodium Hyaluranate to Prevent Postoperative Abdominal Adhesion

作　　者：郑磊[1] 邵斌[1] 任艳丽[1] 孙楠[1] 付强[1] 

机构地区：[1]郑州大学第三附属医院,郑州市450052

出　　处：《医药论坛杂志》2007年第24期48-49,共2页Journal of Medical Forum

摘　　要：目的观察玻璃酸钠预防术后腹腔粘连的作用并探讨其作用机制。方法将38只Wistar大鼠随机分为空白对照组(A组)和璃酸钠给药组(B组),于腹腔内损伤部位分别涂抹生理盐水和玻璃酸钠,术后第21天处死动物,观察各组腹腔粘连情况。结果A组0级粘连0只,Ⅰ级1只,Ⅱ级1只,Ⅲ级5只,Ⅳ级7只;B组0级粘连6只,Ⅰ级7只,Ⅱ级2只,Ⅲ级1只,Ⅳ级0只,经秩和检验两组粘连程度和范围有显著差异(P<0.05)。讨论玻璃酸钠可减轻大鼠术后腹腔粘连程度,为临床防治术后粘连及其并发症提供了一种简单、有效的方法。Objective To evaluate the effect of sodium hyaluranate to prevent postoperative abdominal adhesion and explore their mechanism. Methods Total 38 Wistar rats were divided into 2 groups randomly： Group A （blank Control）, Group B （use sodium hyaluranate）. They were daubed with physiological saline solution and sodium hyaluranate respectively on the injured abdomen cavity. On the day 21 after operation, we observed the abdomen cavity adhesion when the rats were executed. Results There are 0 rat with 0 level adhesion, 1 rat with I level adhesion, 1 rat with II level,5 rats with III level adhesion, and 7 rats with IV level adhesion in group A. Comparatively, There are 6 rats with 0 level adhesion,7 rats with I level adhesion, 2 rats with II level, 1 rat with III level adhesion, and 0 rat with IV level adhesion in group B. The extent and area of adhesion in two groups are different significantly （P 〈 0. 05）. Conclusion Sodium hyaluranate can reduce the extent of postoperative abdominal adhesion obviously, and thus provide a simple and effective methods to prevent postoperative abdominal adhesion and complication.

关 键 词：玻璃酸钠 腹腔粘连 预防 

分 类 号：R656[医药卫生—外科学]