磁性微球靶向栓塞食道/胃底曲张静脉的最佳条件优选  

Targeted embolization of the esophagogastric varices with magnetic microspheres

作　　者：方和平[1] 汤照峰[1] 邓美海[1] 刘波[1] 林楠[1] 许瑞云[1] 

机构地区：[1]中山大学附属第三医院肝胆外科,广州510630

出　　处：《中华实验外科杂志》2007年第12期1496-1498,共3页Chinese Journal of Experimental Surgery

基　　金：广东省科技计划重点项目(20012176);广东省医药卫生科研基金(A2001195)

摘　　要：目的研究聚甲基丙烯酸甲酯磁性微球(简称微球)靶向栓塞食道/胃底曲张静脉的最佳条件,提高栓塞效果。方法通过犬的脾门静脉网的靶向栓塞实验获得最佳磁场强度和最佳磁控时间;以不同粒径的微球靶向栓塞模型犬的食道/胃底曲张静脉,通过病理检查、胃镜、门脉造影评价栓塞效果,优选最佳微球粒径。结果最佳磁场强度为0.4T;最佳磁控时间为30 min;最佳微球粒径是30～50μm和60～100μm。结论以本实验所获条件进行靶向栓塞,效果最佳。Objective To study the optimal conditions （including magnetic field strength, magnetic controlling time and the particle diameter of the magnetic microspheres） of the targeted embolization of esophagogastric varices with polymethylmethacrylate magnetic microspheres （here after referred to as magnetic micrespheres）. Methods （1） Magnetic field strength optimization：Adult hybrid canines were selected to paunch and dissociate venous network of spleen, then coil and cover the venous network with magnetic gastric tubes. The suspension of magnetic micrespheres was dripped into the inlet terminal of the venous network under the conditions of various magnetic field strengths （0. 1,0.2,0.3,0.4 and 0.5 T） and the suspension of magnetic micrespheres that had passed through the venous network at the outlet terminal was collected. By comparing the weights of the suspensions before and after the operation the interception rate of magnetic micrespheres was calculated,and then the optimal magnetic field strength was selected. （2） Magnetic controlling time optimization： As the above method described, after having dripped the suspension of magnetic micrespheres into the inlet terminal of venous network and acting for various periods （5,15,30,45 min） respectively, embolization was observed in the venous networks and the optimal magnetic controlling time was selected. （3） Particle diameter optimization of magnetic microspheres： Esophageal varices models were established in adult hybrid canines. The magnetic gastric tube was inserted into the esophagus/fundus of stomach and the suspension of magnetic microspheres with different particle diameters （10-20,30-50 and 60-100 μm） dripped into the common gastric vein. The optimal magnetic field strength and the optimal magnetic controlling time obtained above were adopted in this experiment and the particle diameter was optimized based on embolization result evaluation through pathological examination, gastroscopic examination, and portal angiography. R

关 键 词：高血压 门静脉 磁性 栓塞 

分 类 号：R657.34[医药卫生—外科学]