生物高分子明胶纳米纤维膜的制备及其应用  

The Preparation and Application of Gelatin Nanofibers Membrane

作　　者：靳钰[1] 李彦凝[1] 聂俊[1] 杨冬芝[1] 

机构地区：[1]北京化工大学材料科学与工程学院,北京100029

出　　处：《塑料》2007年第6期49-52,62,共5页Plastics

基　　金：北京化工大学青年自然科学基金(QN0610)

摘　　要：利用电纺丝技术制备了明胶纳米纤维，系统考察了溶液浓度、电场强度、纺丝距离、喷丝口内径4种因素对纤维膜的形貌以及平均直径的影响；在此基础上，制备了具有较好力学性能的明胶-聚乙烯醇／溶菌酶复合纳米纤维膜，考察了其药物释放性能。结果表明，在上述几种工艺因素中，明胶的浓度对明胶纳米纤维的可纺性以及直径影响较大，当溶液浓度在7％～23％之间能获得连续纤维，并随着浓度的增大，纤维直径也随之增大。纺丝距离10cm、纺丝电压12．5kV是实验中获得连续纤维的临界工艺条件。药物释放结果发现：明胶-聚乙烯醇复合纳米纤维膜对溶菌酶的释放具有一定的缓释效果。Gelatin nanofibers were electrospun from gelatin-formic acid solution. The effect of solution concentration, electrical potential,the distance from spinning tip to collector, inner diameter of metal capillary on the fiber morphology and fiber diameter were discussed. On this basis, gelatin-PVA/lysozyme composite membrane with good mechanical performance was prepared and its control release of lysozyme was investigated. It was found that the solution concentration was strongly correlated with morphology of electrospun fibers,and the resulting solution with a mass concentration in between 7 and 23wt% could be successfully electrospun into nanofibers. When the solution concentration increased,the average fiber diameter increased. The critical voltage to obtain continuous fiber was 12.5kV with a tip-to-collector distance of 10cm. The result of drug release showed Gelatin-PVA composite nano-fiber membrane was useful in controlled lysozyme release.

关 键 词：电纺丝 明胶 纤维 药物缓释 

分 类 号：TQ340.64[化学工程—化纤工业]