中国流行性脑脊髓膜炎流行菌群变化趋势分析  

Epidemiologic Trend of Serogroup Switching of Neisseria meningitidis Strains in China

作　　者：邵祝军[1] 徐丽[1] 高源[1] 李马超[1] 李艺星[2] 尹遵栋[2] 梁晓峰[2] 

机构地区：[1]中国疾病预防控制中心传染病预防控制所,北京102206 [2]中国疾病预防控制中心免疫规划中心,北京100050

出　　处：《中国计划免疫》2007年第6期541-544,共4页Chinese Journal of Vaccines and Immunization

摘　　要：目的 研究中国（未包括香港、澳门特别行政区和台湾地区，下同）流行性脑脊髓膜炎（流脑）流行菌群的变迁趋势。方法 对中国1956～2006年分离的1819株流脑菌株的血清群构成进行分析。结果 1956～2002年的922株流脑菌株中，A群占69．20％，B群占27．55％，C群占0．97％，其它群2．28％。2003～2006年的897株流脑菌株中，A群占35．90％，B群占29．21％，C群占23．97％，其它群占10．92％。C群流脑病人来源菌株比例由0．88％上升至48．67％，A群流脑病例菌株比例由80．4％下降至50．44％。健康人群鼻咽部携带C群流脑菌株比例由1．07％上升至20．41％，A群由58．33％下降至33．80％。结论 中国流脑病人及健康人群携带菌株中，C群流脑菌株的比例呈上升趋势，流脑流行菌群正在发生从A群到C群的变化。Objective To analyze the trend of serogroup switching of Neisseria meningitidis strains in China. Method 1 819 Neisseria meningitidis strains,isolated from 1956 to 2006 in China were analyzed with constituent ratio. Result 922 Neisseria meningitidis strains isolated from 1956 to 2002 were composed of serogroup A （69.20%）,serogroup B（27.55%）,serogroup C （0.97%） and other serogroup strains （2.28%）. From 2003 to 2006, 897 N. meningitidis strains were divided into four mainly groups,including serogroup A （35.90%） ,serogroup B （29.21%）, serogroup C （23.97%） and other serogroup strains （10.92%）. Proportion of N. meningitidis serogroup C strains isolated from invasive meningococcal cases increased from 0. 88% to 48.67%, meanwhile,serogroup A strains decreased from 80.4% to 50.44%. Serogruop C strains from healthy carriers increase from 1.07% to 20.41%, however, serogroup A decreased from 58.33 % to 33.80%. Conclusion It has shown that proportion of serogroup C N. meningitidis strains isolated either from invasive meningococcal cases and from healthy carriers had increasing trend. Serogroups of Neisseria meningitidis were switching from A to C in China.

关 键 词：流行性脑脊髓膜炎 菌群 变化 

分 类 号：R378.15[医药卫生—病原生物学]