塞来昔布对腹腔镜手术术后镇痛的临床研究  

Efficacy of celecoxib for postoperative pain in patients after laparoscopic surgury

作　　者：王永[1] 蒋宗滨[1] 杨学著[1] 张明明[1] 张夏[1] 黄子津[1] 杨冯睿[1] 

机构地区：[1]广西医科大学第一附属医院西院麻醉科,广西医科大学疼痛医学中心,530007

出　　处：《实用疼痛学杂志》2007年第6期431-434,共4页Pain Clinic Journal

摘　　要：目的观察塞来昔布对腹腔镜手术患者的术后镇痛效果及安全性。方法选择住院患者60例,随机分为用药组和对照组。塞来昔布给药方法:术前8～12 h口服2粒,共400mg;术后6 h患者可进食后口服1粒,术后第1、2日每日口服2次(早晚各1次),每次200 mg。观察和记录患者的镇痛效果、不良反应、睡眠满意度及生命体征。结果镇痛效果,用药组与对照组相比,疼痛减轻,清醒后两组比较,用药组清醒后VAS为0.47±1.06;对照组清醒后VAS为2.67±1.68,差异有统计学意义(P<0.05);术后6 h、12 h、24 h以及48 h两组相比差异无统计学意义。用药组不良反应少,基本无睡眠障碍,生命体征平稳。结论塞来昔布用于术后镇痛具有满意的疗效及安全性,适合于腹腔镜手术术后的镇痛治疗。Objective To observe the effect and safety of Celecoxib as an analgesic for patients after laparoscopic surgery. Methods 60 patients with laparosopic surgery were divided into two groups randomly, control group and experiment group. Celecoxib was used as postoperative analgesic in the experiment group. Two capsules（200 mg/each） were taken orally at 8N12 hours before surgery,and then 1 capsule was taken at 6 hours after operation when patients could eat food. Celecoxib was administered 1 capsule twice a day（ morning and evening） in the first and the second day after surgery. VAS, adverse reaction, sleep satisfaction as well as vital signs were observed and recorded in all patients. Results Compared with the control group （ VAS = 2.67±1.68 ）, the experiment group （ VAS = 0.47±1.06 ） showed significant difference （ P 〈0.05 ） in VAS after recovery, and showed no difference at 6 h, 12 h,24 h and 48 h after operation in the two groups. There were few adverse reaction, good sleep satisfaction, stablt vital signs in the experiment group. Conclusion Celecoxib has a satisfactory effect and safety using in postoperative analgesia in patients after laparoscopic surgery.

关 键 词：塞来昔布 腹腔镜外科手术 疼痛 手术后 镇痛 

分 类 号：R614[医药卫生—麻醉学]