Effect of Modified Wuzi Yanzong Granule(加味五子衍宗颗粒)on Patients with Mild Cognitive Impairment from Oxidative Damage Aspect  

作　　者：王学美 富宏 刘庚信 朱伟 李娌 杨金霞 

机构地区：[1]Department of Integrated Chinese and Western Medicine of Peking University First Hospital

出　　处：《Chinese Journal of Integrative Medicine》2007年第4期258-263,共6页中国结合医学杂志（英文版）

基　　金：Supported by Capital Key Science and Technology Program for the Development of Medicine(No.03-Ⅱ-04)

摘　　要：Objective： To observe the effects of modified Wuzi Yanzong Granule （加味五子衍宗颗粒,WYG） on memory function and the activity of serum superoxide dismutase （SOD）, malondialdehyde （MDA） levels, leukocyte mitochondrial DNA （mtDNA） deletion rate and β-amyloid protein1.28 （A β 1-28 ） in patients with mild cognitive impairment （MCl）. Methods： Thirty-six patients with MCl were selected based on the internationally recognized Petersen＇s criteria, and equally and randomly assigned to two groups. The treated group was treated with WYG and the control group was treated with placebo for 3 months. In addition, 20 healthy subjects were included in the study as the normal control group. Changes of memory function, SOD activity, MDA content, leukocyte mtDNA deletion rate and A β 1-28 content were observed before and after treatment. Results： Compared with the normal control group, the memory quotient and SOD activity in patients with MCl decreased significantly （P 〈 0.01）, while MDA, A β1-28 levels and the leukocyte mtDNA deletion rate increased significantly （P 〈 0.01）. After treatment, levels of memory quotient and serum SOD activity increased while the serum MDA level, leukocyte mtDNA deletion rate and A β 1-28 level decreased in the treated group compared with those before treatment （P〈0.01, P〈0.05）. Meanwhile, leukocyte mtDNA deletion rate and A β 1-28 content in the treated group were all lower than those in the control group （P〈0.05）. Conclusion： WYG could improve memory function in patients with MCl and the therapeutic mechanism is possibly related to the increased activity of anti-oxidase, the improved free radical metabolism and the alleviation of leukocyte mtDNA oxidation damage. WYG shows clinical significance in delaying the progression of MCl.Objective： To observe the effects of modified Wuzi Yanzong Granule （加味五子衍宗颗粒,WYG） on memory function and the activity of serum superoxide dismutase （SOD）, malondialdehyde （MDA） levels, leukocyte mitochondrial DNA （mtDNA） deletion rate and β-amyloid protein1.28 （A β 1-28 ） in patients with mild cognitive impairment （MCl）. Methods： Thirty-six patients with MCl were selected based on the internationally recognized Petersen＇s criteria, and equally and randomly assigned to two groups. The treated group was treated with WYG and the control group was treated with placebo for 3 months. In addition, 20 healthy subjects were included in the study as the normal control group. Changes of memory function, SOD activity, MDA content, leukocyte mtDNA deletion rate and A β 1-28 content were observed before and after treatment. Results： Compared with the normal control group, the memory quotient and SOD activity in patients with MCl decreased significantly （P 〈 0.01）, while MDA, A β1-28 levels and the leukocyte mtDNA deletion rate increased significantly （P 〈 0.01）. After treatment, levels of memory quotient and serum SOD activity increased while the serum MDA level, leukocyte mtDNA deletion rate and A β 1-28 level decreased in the treated group compared with those before treatment （P〈0.01, P〈0.05）. Meanwhile, leukocyte mtDNA deletion rate and A β 1-28 content in the treated group were all lower than those in the control group （P〈0.05）. Conclusion： WYG could improve memory function in patients with MCl and the therapeutic mechanism is possibly related to the increased activity of anti-oxidase, the improved free radical metabolism and the alleviation of leukocyte mtDNA oxidation damage. WYG shows clinical significance in delaying the progression of MCl.

关 键 词：modified Wuzi Yanzong Granule mild cognitive impairment memory function oxidative damage β -amyloid protein 

分 类 号：R277.7[医药卫生—中医学]