藻酸双酯钠脂质体的制备及粒度分布的测定  

Preparation of aliginic sodium diester liposome and measurement of its size distribution

作　　者：王继波[1] 岳旺[1] 孙衍增[1] 张玲玲[1] 吕国凤[1] 

机构地区：[1]青岛大学医学院药学系,山东青岛266021

出　　处：《中国海洋药物》2007年第6期28-31,共4页Chinese Journal of Marine Drugs

摘　　要：目的制备藻酸双酯钠脂质体并对其聚结稳定性进行评价。方法采用蛋黄卵磷脂为包封材料,逆向蒸发法制备藻酸双酯钠脂质体,将藻酸双酯钠脂质体与空白脂质体对照,分别测定了它们经37℃,40h温育前后的粒度分布,计算平均粒径。结果在n(PC)∶n(CHOL)=1∶1的条件下,藻酸双酯钠脂质体的平均粒径为4.24μm,温育后,藻酸双酯钠脂质体的平均粒径只增加了0.26μm,而空白脂质体的平均粒径增加了1.35μm。结论藻酸双酯钠载于脂质体上,提高了脂质体的聚结稳定性。Objective Aliginic sodium diester （ASD） liposome was prepared and its aggregation stability was evaluated. Methods ASD liposome was made by reverse phase evaporating method from egg yolk lecithin, compared with blank liposome, the size distributions and mean particle diameters of ASD liposome and blank liposome were measured respectively before and after 40 hours heating under 37℃. Results Under the condition of n （PC） ： n （CHOL） = 1 ： 1,the mean size diameter of ASD liposome was 4.24μm. The mean size diameter of ASD liposome changed only 0.26μm after cultivation, however, the value of blank liposome was 1.35μm. Conclusion ASD loaded in the liposome enhanced the physical stability of the liposome.

关 键 词：藻酸双酯钠 脂质体 制备 粒度分布 

分 类 号：R972[医药卫生—药品] TQ460[医药卫生—药学]