老年2型糖尿病患者血清可溶性细胞间黏附分子1与颈动脉硬化的关系  

Relationship between serum soluble intercellular adhesion molecule-1 and carotid atherosclerosis in elderly type 2 diabetic patients

作　　者：郭远[1] 孙立新[1] 樊春红[2] 杨铁生[2] 赵红薇[3] 薛利芳[4] 

机构地区：[1]北京大学人民医院老年科,100044 [2]北京大学人民医院检验科,100044 [3]北京大学人民医院血管中心,100044 [4]北京大学人民医院超声科,100044

出　　处：《中华老年医学杂志》2007年第12期896-899,共4页Chinese Journal of Geriatrics

摘　　要：目的初步探讨老年2型糖尿病患者血清细胞间黏附分子1（sICAM-1）与颈动脉硬化的关系。方法测定108例2型糖尿病患者（糖尿病组）与46例老年健康体检者（对照组）血清sICAM-1、生化指标及颈动脉内中膜厚度（IMT）,根据IMT将糖尿病患者分为：IMT正常组（30例）、IMT增厚组（28例）、斑块组（50例）;将斑块组再分为稳定斑块亚组（34例）、不稳定斑块亚组（16例）,进行分析。结果糖尿病组血清sICAM-1水平显著高于对照组（P〈0.05）;IMT正常组、IMT增厚组、斑块组sICAM-1水平逐步升高（P〈0.05）;不稳定斑块亚组高于稳定斑块亚组（P〈0.05）。血清sICAM-1水平与三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、糖化血红蛋白（HbA1c）、高敏C反应蛋白（HsCRP）呈正相关。结论老年糖尿病患者血清sICAM-1水平与颈动脉硬化程度及斑块稳定性有关,其升高与慢性高血糖、脂代谢紊乱及炎症反应相关。Objective To investigate the relationship between serum soluble intercellular adhesion molecule-1 （sICAM-1） and carotid atherosclerosis in elderly patients with type 2 diabetes mellitus （T2DM）. Methods The serum levels of sICAM-1 and carotid intima-media thickness （IMT） were measured by ELISA and Doppler ultrasound in 108 elderly cases of T2DM and 46 elderly cases of healthy controls. Based on IMT, DM patients were divided into three groups： IMT normal group, IMT thickened group and plaque group. Results The serum levels of sICAM-1 in elderly T2DM were higher than those in healthy controls （P〈0. 05）. Among elderly T2DM patients, the serum level of sICAM-1 was higher in IMT thickened group than in IMT normal group（P〈0. 05） ,and lower than in plaque group（P〈0. 05）. Furthermore, the serum levels of sICAM-1 in patients with unstable plaques were higher than in those with stable plaques（P〈0.05）. The change of serum level of sICAM-1 was positively correlated with triglyceride （TG）, low density lipoprotein cholesterol （LDL-C）, hemoglobin Alc （ HbAlc）, high-sensitive C-Reaction protein（hs-CRP） . Conclusions Among elderly T2DM patients, the serum level of sICAM-1 might be related to the extent of carotid atherosclerosis and plaques stability; the elevation of the serum level of sICAM-1 is correlated with TG, LDL-C, HbAlc and chronic inflammation.

关 键 词：糖尿病 2型 细胞间黏附分子1 颈动脉疾病 动脉硬化 

分 类 号：R686[医药卫生—骨科学]