甲羟戊酸5-焦磷酸脱羧酶及其抑制研究进展  

Progress in Mevalonate 5-Diphosphate Decarboxylase and Its Inhibition

作　　者：邱永革[1] 林景隆[1] 

机构地区：[1]韩山师范学院化学系,广东潮州521041

出　　处：《韩山师范学院学报》2007年第6期73-82,共10页Journal of Hanshan Normal University

摘　　要：甲羟戊酸5-焦磷酸脱羧酶(MDD)是甲羟戊酸途径中的一种重要的酶,它在调节胆固醇等类异戊二烯化合物的生物合成方面起重要作用,有可能成为治疗心血管疾病和癌症的靶标。该文总结了MDD在催化机理、蛋白结构、序列对比分析与残基功能,及其抑制剂研究等方面的成果。Mevalonate 5-diphosphate decarboxylasc （MDD） converts mevalonate diphosphate to isopentenyl diphosphate, which plays an important role in regulating cholesterol biosynthesis and may become a target for treatment of cardiovascular diseases and cancers. It is of increasing interest to the study of MDD and its inhibition in recent decades. The current knowledge of MDD is summarized in the article, which may be useful for further investigation in the field of the enzyme.

关 键 词：甲羟戊酸5-焦磷酸脱羧酶 胆固醇 甲羟戊酸途径 抑制作用 

分 类 号：Q557[生物学—生物化学] O629.8[理学—有机化学]