塞来昔布对腹腔镜手术术后镇痛的临床研究  

The Clinical Research of Efficacy of Celecoxib in the Treatment of Postoperative Pain in Laparosopic Surgery Patients

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作  者:蒋宗滨[1] 王永[1] 杨学著[1] 何睿林[1] 黄子津[1] 杨冯睿[1] 

机构地区:[1]广西医科大学疼痛医学中心,南宁530007

出  处:《麻醉与监护论坛》2007年第6期354-356,共3页Forum of Anesthesia and Monitoring

摘  要:目的:观察塞来昔布对腹腔镜手术患者的术后镇痛效果及安全性。 方法:选择住院病人60例,随机分为用药组和对照组。塞来昔布给药方法:术前8~12h口服两粒;术后6h患者可进食后口服一粒,术后第一、二天每天口服两次(早晚各一次),每次一粒。观察和记录患者的镇痛效果,不良反应,睡眠满意度及生命体征。 结果:镇痛效果,用药组与对照组相比,疼痛减轻,清醒后两组比较有显著差异(P〈0.05);术后6h、12h、24h以及48h两组相比均无明显差异。用药组不良反应少,基本无睡眠障碍,生命征平稳。结论:塞来昔布用于术后镇痛具有满意的疗效及安全性,适合于腹腔镜手术术后的镇痛治疗。Objective: To observe the effect and the safety of the Celecoxib as the analgesic in laparoscopic surgery patients. Methods: 60 cases of laparosopic surgery patients were divided into two groups randomly. Celecoxib was used as the postoperative analgesic in the experiment group and the rest in the control group. The administration of Celecoxib was as follows: 2 capsules were taken at 8-12 hours before surgery by oral, and then 1 capsule was taken at 6 hours after operation when patients could eat food. Celecoxib was administered 1 capsule twice a day(in the morning and evening) at the first and the second postoperative day. VAS score, adverse reaction, the sleep satisfaction of the patients and the vital signs were observed and recorded. Results: Compared with the control group, the experiment group showed significant difference(P〈0.05) in VAS after recovery, and the two groups showed no difference at 6h, 12h, 24h and 48h after operation. They were fewer adverse reaction, better sleep satisfaction and more stable vital signs in the experiment group. Conclusion: Celecoxib demonstrated a satisfactory effect and safety using in postoperative analgesia in laparoscopic surgery patients.

关 键 词:塞来昔布 腹腔镜手术 术后镇痛 

分 类 号:R971.2[医药卫生—药品] R656[医药卫生—药学]

 

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