肾移植受者环孢素A与盐酸小檗碱合用的临床研究  

A clinical study on coadministration of Cyclosporin A and berberin hydrochloride in renal transplanted recipients

作　　者：余爱荣[1] 辛华雯[1] 吴笑春[1] 李罄[1] 

机构地区：[1]广州军区武汉总医院临床药理科

出　　处：《中国临床药理学与治疗学》2007年第12期1415-1418,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：湖北省自然科学基金资助课题(2002AB114);全军杰出人才基金课题

摘　　要：目的:研究肾移植受者长期联合应用盐酸小檗碱(berberine hydrochloride,Ber)与环孢素A(Cyclos- porin A,CsA)对CsA血浓度和肝、肾功能的影响。方法:138名服用CsA+Ber患者为试验组,150名单服CsA患者为对照组,以CsA全血浓度及肝、肾功能生化检测指标作为临床评价指标。结果:试验组合用Ber 1、3、6个月后CsA浓度比合用前增加49.8%、81.4%和36.9%(P<0.01),CsA浓度/剂量的比值比合用前增加88.8%、102.0%和72.5%(P<0.01),与对照组比较差异均有统计学意义(P<0.01)。Ber与CsA合用对肝、肾功能无明显影响。结论:Ber能明显升高肾移植受者CsA血浓度.且不增加CsA的毒性反应,因此可减少CsA用药量,节省费用。AIM： To study the effect of berberin hydrochloride （Ber） on the elevation of blood concentration of Cyclosporin A （CsA） and liver and renal functions in renal transplanted recipients. METHODS： 138 cases with renal transplantation in experimental group were treated with CsA and Ber and 150 cases with renal transplantation in control group received CsA only. Blood levels of CsA, biochemistry indexes for liver and renal function were determined. RESULTS： After 1,3,6 months combined with Ber, blood concentrations of CsA in patients went up by 49.8% ,81.4% ,36.9% and the radios of blood concentration of CsA to CsA dosage increased 88.8%, 102.0%, 72.5% compared with those before taking Ber（ P 〈 0.01 ）. It had a significant increase compared with the control group（ P 〈 0.01）. No significant effect on liver or renal function was observed when combined with Bet and CsA. CONCLUSION： Ber could markedly elevate the blood concentration of CsA in renal transplanted recipients and did not increase the toxicity of CsA. Ber combined with CsA can be used as a method for saving money on CsA.

关 键 词：肾移植 环孢素A 盐酸小檗碱 血药浓度 临床研究 

分 类 号：R969[医药卫生—药理学]