冠心病与IFN-γ和sICAM-1浓度关系的研究  

Relationship between Coronary Heart Disease and Concentrations of IFN-γ and sICAM-1

作　　者：杭永伦[1] 林江[1] 杨明学[1] 刘应才[2] 

机构地区：[1]泸州医学院附属医院检验科,四川省泸州市646000 [2]泸州医学院心内科,四川省泸州市646000

出　　处：《医学理论与实践》2008年第1期15-16,共2页The Journal of Medical Theory and Practice

摘　　要：目的:检测γ干扰素(IFN-γ)和可溶性细胞内粘附分子-1(sICAM-1)的浓度,并分析它们与冠心病(CHD)急性心肌梗死(AMI)及不稳定性心绞痛(UAP)的关系。方法:对CHD组和正常对照组用酶联免疫吸附试验(ELISA法)检测IFN-γ和sICAM-1的浓度,并进行统计分析。结果:AMI及UAP患者血清中IFN-γ和sICAM-1浓度均明显高于正常对照组(P<0.05或P<0.01),AMI和UAP患者间IFN-γ浓度无显著性差异,AMI患者sICAM-1浓度比UAP患者明显升高(P<0.01)。结论:提示IFN-γ和sICAM-1可能参与了CHD的发生、发展过程。sICAM-1浓度与CHD的严重程度呈正相关,是一个比IFN-γ更好的CHD独立预测因子。Objective：To measure the concentrations of interferon-gamma（IFN-γ） and soluble intercellular adhesion molecule-1（sICAM-1）,to assess their correlation with acute myocardial infarction（AMI） and unstable angina group（UAP） of coronary heart disease（CHD）.Methods：The serum concentrations of IFN-γ and sICAM-1 CHD patients and healthy controls were determined by enzyme-linked immunosorbent assay（ELISA assay）,and compared with healthy controls.Results：Significant increases were noted in serum IFN-γ and sICAM-1 in patients with AMI and UAP compared with healthy controls（P〈0.05 or P〈0.01）.Serum IFN-γ was not significantly different between the AMI and UAP.Significant increases was noted in serum sICAM-1 in patients with AMI compared with UAP（P〈0.01）.Conclusion：IFN-γand sICAM-1 might be implicated in the pathogenesis of the atherosclerosis in CHD.The serum concentration of sICAM-1 was significantly correlated with severity extent of CHD.It was a good predicting factor for CHD than the IFN-γ.

关 键 词：冠心病 Γ干扰素 可溶性细胞内粘附分子-1 动脉粥样硬化 

分 类 号：R541.4[医药卫生—心血管疾病]