人参皂甙对培养成年大鼠心肌细胞收缩功能影响的研究  

Effect of Ginsenoside on cardiac contraction in adult rat ventricular myocytes

作　　者：王影[1] 郝艳玲[2] 孙义伟[2] 孙红[2] 姜春玲[3] 

机构地区：[1]徐州医学院病理生理学教研室,江苏徐州221002 [2]徐州医学院生理学教研室 [3]大连医科大学生理学教研室,辽宁大连116027

出　　处：《徐州医学院学报》2008年第1期19-21,共3页Acta Academiae Medicinae Xuzhou

基　　金：江苏省教育厅指导性课题(04KJD310208)

摘　　要：目的观察人参皂甙(Ginsenosides,Gs)对体外培养的成年大鼠心肌细胞收缩功能的影响。方法采用体外培养的成年大鼠心肌细胞,观察不同浓度的Gs(12.5、25、50、100、200mg/L)对心肌细胞收缩功能的影响。结果与正常对照组比较,加入不同浓度的Gs干预的各组,随着Gs浓度升高,心肌细胞收缩功能明显降低(P<0.01)。结论25mg/L以上浓度Gs能降低正常成年大鼠心肌细胞的收缩幅度。Objective To investigate the effect of Ginsenosides （Gs） on cardiac contraction in adult rat ventricular myocytes. Methods Cultured cardiomyocytes from adult rat were used in the study, with the cardiomyocytes cultured with five different concentrations of Gs（ 12.5, 25, 50, 100 and 200 mg/L）separately. The contraction was recorded in terms of amplitude. Results Compared with control group, Gs significantly decreased the contraction amplitude of myocytes as the concentration of Gs was increased（ P 〈 0.01 ）. Conclusion Gs of concenation over 25 mg/L can decrease cardiac contraction in adult rat ventricular myocytes.

关 键 词：人参皂甙 心肌细胞 收缩功能 

分 类 号：R331.36[医药卫生—人体生理学]