385例癫患者血药浓度监测分析  

Monitoring of serum drug concentration in 385 epileptic patients

作　　者：王来成[1] 李相涛[1] 王涛[1] 

机构地区：[1]徐州医学院附属医院药剂科,江苏徐州221002

出　　处：《徐州医学院学报》2008年第1期63-64,共2页Acta Academiae Medicinae Xuzhou

摘　　要：目的通过血药浓度监测了解常规应用抗癫药患者的血药浓度情况,为临床合理用药提供参考。方法采用荧光偏振免疫法对385例癫患者进行血药浓度监测。结果监测446例次中,低于有效血药浓度202例次,占45·3%,高于有效血药浓度34例次,占7.6%。结论癫患者常规经验用药的血药浓度个体差异较大,血药浓度监测对个体化用药具有重要意义。Objective To investigate the situation in the elinical use of antiepileptic drugs （AEDs ） so as to rationalize their clinical use. Methods The serum concentration of AEDs in 385 epileptie patients was determined by fluorescence polarization immunoassay. Results Analysis of the 446 tests performed in the study revealed that the serum level was below the effective serum drug concentrations in 202 （45.3%） tests, and above the effective concentration in 34 （7.6%） tests. Conclusion Since the range of effective AEDs level is rather narrow and the patients react to the drug differently, it is important to monitor serum drug concentrations to individualize the dosage of AEDs for certain patients.

关 键 词：抗癫痫药 血药浓度 荧光偏振免疫法 

分 类 号：R969.3[医药卫生—药理学] R749.17[医药卫生—药学]