α-氰基丙烯酸酯及其衍生物的合成与农药生物活性研究进展  

Recent Advances in the Synthesis and Biological Activity on Pesticide ofα-Cyanoacrylates and Its Analognes

作　　者：张慧苹[1] 宋宝安[1] 王献友[1] 龙宁[1] 胡德禹[1] 杨松[1] 薛伟[1] 卢平[1] 金林红[1] 

机构地区：[1]贵州大学精细化工研究开发中心,教育部绿色农药与生物工程重点实验室,贵阳550025

出　　处：《有机化学》2008年第1期17-28,共12页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No．20672024);国家973重点基础研究发展计划(No．2003CB114404);国家“十一·五”科技支撑计划(No．2006BAE01A02-5)资助项目

摘　　要：丙烯酸酯是一类具有良好生物活性的化合物,由于它作用机制新颖、环境友好,故其分子设计和合成及生物活性成为目前农药创制的热点之一,按其在农药应用方面的不同活性作用进行分类,综述了丙烯酸酯及其类似物的合成、生物活性与除草活性方面构效关系的研究进展.Cyanoacrylates and their analogues are an important class of compounds with high bioactivities. Recently, studies on the molecular designing, synthesizing and bioactivities of α-cyanoacrylates have attracted more and more attentions according to their characteristics of novel mechanism and friendly-environment. Recent advances in the synthesis, structure, biological activity and structure-activity relationships （SAR） of 2-cyanoacrylate and its analogues are reviewed emphatically on their applying on pesticide based on different bioactivities.

关 键 词：丙烯酸酯 合成 生物活性 构效关系 

分 类 号：TQ450.1[化学工程—农药化工]