2004-2005年中国社区获得呼吸道感染常见病原菌耐药性研究  

Antibiotic resistance of common pathogens isolated from community-acquired respiratory infection in China during 2004—2005

作　　者：孙宏莉[1] 徐英春[1] 王辉[1] 杨启文[1] 胡必杰[2] 刘勇[3] 王选锭[4] 张天托[5] 陈文昭[6] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院检验科,北京100730 [2]上海复旦大学附属中山医院 [3]中国医科大学第二临床学院 [4]浙江大学附属二院 [5]广州中山大学附属三院 [6]四川大学华西医院

出　　处：《中国感染与化疗杂志》2008年第1期24-29,共6页Chinese Journal of Infection and Chemotherapy

摘　　要：目的调查中国6所教学医院2004--2005年分离的社区获得呼吸道感染常见病原菌的耐药性。方法收集2004年7月-2005年3月全国6个地区6所医院社区获得呼吸道感染患者中分离的510株肺炎链球菌、流感嗜血杆菌、卡他莫拉菌、p溶血链球菌及MSSA、非产ESBLs的肺炎克雷伯菌和大肠埃希菌，以琼脂稀释法测定头孢泊肟等9种抗菌药物的MIC。结果肺炎链球菌中，青霉素敏感肺炎链球菌（PSSP）、青霉素中介肺炎链球菌（PISP）、青霉素耐药肺炎链球菌（PRSP）对头孢泊肟的敏感率分别为98．9％、42．2％、6．4％。肺炎链球菌对莫西沙星的敏感率为100％；对米诺环素的敏感率为94．6％；对阿奇霉素的敏感率仅为10．7％；流感嗜血杆菌、MSSA、非产ESBL的肺炎克雷伯菌和大肠埃希菌对头孢泊肟、头孢丙烯、头孢克洛、莫西沙星和米诺环素的敏感率在51．3％～100％。结论呼吸道病原菌特别是肺炎链球菌、流感嗜血杆菌的耐药率与往年监测结果相比较呈增加趋势；头孢泊肟对呼吸道病原菌的抗菌活性优于头孢丙烯和头孢克洛。Objective To investigate the antimicrobial resistance of common pathogens isolated from community-acquired respiratory infection in China. Methods A total of 510 strains were isolated from patients with community-acquired respiratory tract infection at six hospitals in China from July 2004 to March 2005, including Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, β-hemolytic Streptococcus, oxacillin-susceptible Staphylococcus a ureus （MSSA）, non-ESBLs- producing K. pneumoniae and E. coli. Agar dilution method was used to determine the minimum inhibitory concentration （MIC） of cefpodoxime and other eight antibiotics against these strains. Results About 98.9% of penicillin-susceptible S. pneu- moniae （PSSP）, 42. 2% of penicillin-intermediate S, pneumoniae （PISP） and 6. 4% of penicillin-resistant S. pneumoniae （PRSP） isolates were susceptible to cefpodoxime. Moxifloxacin, minocycline and azithromycin inhibited 100%, 94.6% and 10.7% of the S. pneumoniae isolates respectively. The proportion of Haemophilus influenzae, MSSA, non-ESBLs-producing K. pneumoniae and E. coli isolates susceptible to cefpodoxime, cefprozil, cefaclor, moxifloxacin or minocycline ranged from 51. 3% to 100%. Conclusions The antibiotic resistance is increasing in common pathogens from community respiratory tract infections, especiall.y S. pneumoniae and H. influenzae compared with the data of previous years activity of cefpodoxime seems superior to cefaclor. The antimicrobial that of cefprozil or

关 键 词：肺炎链球菌 社区获得呼吸道感染 耐药性 头孢泊肟 

分 类 号：R446.5[医药卫生—诊断学]