武汉地区61株鼠伤寒沙门菌的耐药性分析  

Antimicrobial resistance of 61 isolates of Salmonella typhimurium

作　　者：陈静[1] 孙自镛[1] 李丽[1] 朱旭慧[1] 张蓓[1] 杜鹏超[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院检验科,武汉430030

出　　处：《中国感染与化疗杂志》2008年第1期47-49,共3页Chinese Journal of Infection and Chemotherapy

摘　　要：目的了解本地区门诊腹泻患者鼠伤寒沙门菌（STM）的耐药性。方法采用商用培养基及沙门菌诊断血清分离、鉴定细菌；抗菌药物敏感性试验采用琼脂稀释法检测MIC。结果STM检出率为0．6％（61／10464），其对氨苄西林、氯霉素、四环素、复方磺胺甲嗯唑、阿莫西林-克拉维酸、环丙沙星和庆大霉素耐药率达71．2％～100％。第三代和第四代头孢菌素对STM仍维持较好的抗菌活性，耐药率均低于3．3％。未检出亚胺培南耐药株。61株STM中，多重耐药菌占88．5％。结论本地区腹泻患者粪便标本中STM对亚胺培南和第三代、第四代头孢菌素较敏感，对氨苄西林、氯霉素、四环素、复方磺胺甲嗯唑、庆大霉素和阿莫西林-克拉维酸等耐药性较严重，应加强其耐药性监测和防治。Objective To investigate the resistance of S. typhimurium isolated from outpatients with diarrhea. Methods The S. typhimurium isolates were identified by biochemical test and traditional serological methods. Minimum inhibitory concentration was determined for these isolates by agar dilution method according to the criteria of CLSL Results Sixty-one strains of S. typhimurium were isolated from 10 464 samples （0.6%）. The resistance rates of S. typhimuriurn to ampicillin, chloram- phenicol, tetracycline, sulfamethoxazole-trimethoprim, amoxicillin-clavulanic acid, ciprofloxacin and gentamicin ranged from 71.2% to 100%. The extended-spectrum cephalosporins （ESC） showed high antibacterial activity against S. typhirnuriurn. Less than 3.3% of the isolates were resistant to these ESC agents. We found no isolates resistant to imipenem. Muhidrug resistant （MDR） S. typhimurium accounted for 88.5% （54/61）. Conclusions Most isolates of S. typhimurium are resistant to many antimicrobial agents except imipenem and ESC. More attention should be paid to the surveillance and control of such reslstance

关 键 词：鼠伤寒沙门菌 最低抑菌浓度 多重耐药性 

分 类 号：R446.5[医药卫生—诊断学]