替硝唑在水溶液中溶解度的实验测定及关联  

Measurement and correlation of tinidazole solubilities in water systems

作　　者：邹莹[1] 刘永琼[1] 祝宏[1] 王剑[1] 

机构地区：[1]武汉工程大学化工与制药学院绿色化工过程省部共建教育部重点实验室湖北省新型反应器与绿色化学工艺重点实验室,湖北武汉430074

出　　处：《武汉工程大学学报》2008年第1期7-9,16,共4页Journal of Wuhan Institute of Technology

摘　　要：通过自制的固-液平衡装置，采用高效液相色谱法分别测定了温度在278．15～318．15K时替硝唑在纯水、5％葡萄糖溶液和0．9％氯化钠溶液中的溶解度，并对实验数据分别采用理想溶液模型和经验方程进行了关联．对于纯水体系和0．9％氯化钠溶液体系，实验数据用理想溶液模型关联能较满意地表征实验结果．两种关联方法中，经验方程能较好地关联所测得的溶解度数据，误差较小．The solubilities of tinidazole in water,5% glucose and 10%NaCl solutions,were measured by using a solid-liquid equilibrium cell at 278.15 - 318.15 K, respectively. And the ideal solution model and a empirical equation were applied to correlate the solid-liquid equilibrium data. The solubility data obtained in water and 5% glucose solution systems are correlated with the idea solution model with satisfactory results. And the empirical equation can correlated the solubility data well with a lower error between the two correlated methods.

关 键 词：替硝唑 溶解度 固液平衡 高效液相色谱 理想溶液模型 经验方程 

分 类 号：R978.1[医药卫生—药品]