手性色谱固定相拆分手性药物坦索罗辛  

Chiral Stationary Phase for Resolution of Tamsulosin Hydrochloride

作　　者：薛洪宝[1] 胡进勇[1] 钟延霞[1] 刘庆彬[1] 

机构地区：[1]河北师范大学化学化工研究所

出　　处：《河北师范大学学报（自然科学版）》2008年第1期81-84,共4页Journal of Hebei Normal University：Natural Science

基　　金：河北省自然科学基金(B2005000151)

摘　　要：采用天然手性中心多糖类手性反相色谱固定相填料,高氯酸钠水溶液和乙腈为流动相,在不同的流动相比例下拆分了手性药物坦索罗辛.研究了该化合物在不同条件下色谱参数变化的规律,包括保留时间、分离度、塔板数、半峰宽度、对称度等.得到了较好的拆分该手性化合物的色谱条件.Using a natural polysaccharide-derived loading material as chiral stationary phase,sodium perchlorate solution and acetonitrile as mobile phase, racemic tamsulosin hydrochloride was separated by adjusting different proportion of mobile phase. The HPLC parameters of this compound, including retention time, degree of separation,number of plates, half peak breadth, degree of symmetry was studied in the different condition. The excellent condition of separation racemic tamsulosin hydrochloride was obtained.

关 键 词：手性固定相 手性分离 坦索罗辛 

分 类 号：O658[理学—分析化学]