硫酸镁对重度子痫前期患者血清尾加压素Ⅱ水平的影响  

Effects of Magnesium Sulfate on Levels of Plasma Urotensin Ⅱin Patients with Severe Preeclampsia

作　　者：吴文英[1] 徐春琳[1] 李海霞[2] 王玉红[1] 

机构地区：[1]河北医科大学第二医院妇产科,河北省石家庄市050000 [2]河北省唐山市丰润区人民医院妇产科

出　　处：《中国全科医学》2008年第2期111-112,共2页Chinese General Practice

摘　　要：目的研究静脉滴注硫酸镁对重度子痫前期患者血清尾加压素Ⅱ(UrotensinⅡ,UⅡ)水平的影响。方法对68例重度子痫前期患者静脉滴注硫酸镁治疗3d,比较治疗前后血清UⅡ水平、平均动脉压(mean arterial pressure,MAP)、脐动脉血流收缩期与舒张期比值(umbilical artery systolic/diastolic ratio,S/D)及阻力指数(resistant index,RI)以及24h尿蛋白含量的变化,并记录自觉症状。结果(1)治疗前后血清UⅡ水平、MAP、S/D及RI、24h尿蛋白定量水平间差异均有统计学意义(P<0.05)。(2)治疗前后血清UⅡ与MAP、S/D及RI、24h尿蛋白均呈正相关关系(P<0.05)。(3)治疗后症状未消失的患者与症状消失的患者血清UⅡ下降值间差异有统计学意义(P<0.05)。结论硫酸镁可使重度子痫前期患者的血清UⅡ水平降低,UⅡ可能参与了妊娠期高血压疾病的发生、发展过程。Objective To study the effects of magnesium sulfate （MgSO4） by intervenous （IV） drop on levels of plasma urotensin （ U - Ⅱ） in patients with severe preeclampsia. Methods 68 cases with severe preeclampsia were given IV drops of MgSO4 for 3 days. We compared plasma U - Ⅱ levels, mean arterial pressure （MAP）, umbilical artery systolic/diastolic ratio （S/D） and resistant index （ RI）, 24h urine protein levels before and after treatment, and recorded subjective symptoms. Results （ 1 ） There was significant difference in the levels of plasma U - Ⅱ , MAP, S/D, RI and 24h urine protein between pre - treatment and post - treatment （ P 〈 0. 05 ）. （2） The levels of U - Ⅱ were positively correlated with the levels of MAP, S/D and RI, 24h urine protein before and after the treatment （ P 〈 0. 05）. （3）. There was significant difference in descending rate of U - Ⅱ between patients in whom subjective symptoms had not disappeared and those in whom subjective symp- toms had disappeared （ P 〈 0. 05）. Conclusion MgS04 can decrease the levels of U - Ⅱ in patients with severe preeclampsia, U - Ⅱ may be correlated with pregnancy induced - hypertension syndrome.

关 键 词：子痫前期 硫酸镁 尾加压素Ⅱ 平均动脉压 

分 类 号：R714.24[医药卫生—妇产科学]