铜绿假单胞菌对碳青霉烯类抗生素5年耐药率的分析  

Resistance change of pseudomonas aeruginosa to carbapenems in five years

作　　者：李庆兴[1] 郑宇[1] 张慧芳[1] 陈迎晓[1] 王邦松[1] 

机构地区：[1]温州医学院第一临床学院感染内科,温州325000

出　　处：《中国临床药学杂志》2008年第1期51-52,共2页Chinese Journal of Clinical Pharmacy

摘　　要：目的探讨医院内铜绿假单胞菌(PA)对碳青霉烯类抗生素的耐药率及其变迁,以指导临床合理用药。方法采集2001-2005年病房临床分离PA共2 629株,测定对碳青霉烯类抗生素的药敏。结果对亚胺培南和美洛培南的5 a总耐药率分别是49.54%和55.57%。2001年对亚胺培南的耐药率是47.86%,2005年上升到60.59%(P<0.01)。2003年对美洛培南的耐药率是36.63%,2.005年上升到75.23%(P<0.01)。结论PA对碳青霉烯类抗生素的耐药性已十分突出,对于PA的感染,应在药敏指导下用药。碳青霉烯类抗生素的耐药性呈明显上升趋势,应该适当控制碳青霉烯类药物的使用。AIM To investigate the change of resistance of Pseudomonas aeruginosa （PA） to carbapenems for rational usage of antimicrobialagent. METHODS The 2 629 PA strains were tested, which were separated from clinical specimen from Jan. 2001 to Dec. 2005. Snsceptitities to cabapenems were determined. RESULTS Resistance rate of imipenem was 49.54 %, and meropenem was 55.57 %. In 2001, the resistant rate of imipenem was 47.86%, while it increased to 60.59% （ P 〈 0.01 ）in 2005. In 2003, the resistant rate of meropenem was 36.63% ,while it increased to 75. 23 % （ P 〈 0.01） in 2005. CONCLUSION The resistance rate of PA to carbapenems is obviously increasing. Antimicrobial treatment of PA infections should be guided by antimicrobial sensitivity test. The clinical usage of carbapenems should be strategically controlled.

关 键 词：铜绿假单胞菌 碳青霉烯类抗生素 耐药性 

分 类 号：R446.5[医药卫生—诊断学]