以积雪苷为脱色剂的新Kligman配方治疗黄褐斑临床观察  

Therapeutic effects of new Kligman formula based on the depigmention agent asiaticoside on melasma

作　　者：鲁严[1] 吴迪[1] 王大光[1] 

机构地区：[1]南京医科大学第一附属医院皮肤科,江苏南京210029

出　　处：《中国美容医学》2008年第1期113-115,共3页Chinese Journal of Aesthetic Medicine

基　　金：江苏省社会发展计划资助(编号:BS2007072)

摘　　要：目的:Kligman配方是以脱色剂(氢醌或曲酸等)、维A酸和皮质类固醇激素联合外用治疗黄褐斑的有效疗法,我们用积雪苷代替传统脱色剂,观察新Kligman配方治疗黄褐斑的疗效。方法:将黄褐斑患者随机分为三组:传统Kligman配方组:21例,外用4%氢醌+0.1%维A酸+0.1%丁酸氢化可的松;新Kligman配方组:30例,外用0.25%积雪苷+0.1%维A酸+0.1%丁酸氢化可的松;对照组:18例,外用积雪苷乳膏基质+0.1%维A酸+0.1%丁酸氢化可的松,每晚外用一次,分别于第4周、8周观察疗效。结果:4周后三组有效率分别为76.19%、53.33%、6.67%,8周后三组有效率分别为85.71%、83.33%、50.00%,新Kligman配方组疗效与传统Kligman配方疗效差别无统计学意义(P>0.05)。结论:本研究表明以积雪苷为脱色剂的新Kligman配方能有效治疗黄褐斑。Objective Kligman formula is a combination of depigmention agents （hydroquinone or kojic acid etc）, retinoic acid and corticosteroids for topically use to treat melasma. In this study, we alternatively used asiaticoside to replace traditional depigmention agents in the formula and observed its therapeutic effects on melasma. Methods Patients in our clinic dated from Oct. 2006 to Jun. 2007 were randomly divided into three groups： 21 cases in Group A （hydroquinone＋ retinoic acid＋ hydrocortisone Butyrate）, 30 cases in Group B （asiaticoside＋ retinoic acid＋ hydrocortisone） and 18 cases in Group C （vehicle＋ retinoic acid＋ hydrocortisone）. They were supervised to topically use the combina- tions respectively once a night, and effects were observed at week 4 and week 8. Results The curing rates were 76.19%, 53.33% and 16.67% in Group A, B and C at week 4 and 85.71%, 83.33%, 50.00% at week 8, respectively. There was no statistical difference in the therapeutic effects between Group A and B. Conclusion New formula based on the depigmentation agent asiaticoside is a potential strategy in the treatment of melasma.

关 键 词：黄褐斑 积雪苷 Kligman配方 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]