苯骈呋喃酮类化合物的质谱裂解特征研究  

STUDY OF MASS SPECTRUM CHARACTERIZATION OF THE BENZOFURANONE COMPOUNDS

作　　者：牛占旗[1] 牛锋[2] 孟芳[2] 孙玉明[3] 韩健[4] 陈大为[1] 

机构地区：[1]沈阳药科大学药学院药剂系,辽宁沈阳110016 [2]石药集团恩必普药业有限公司研发部,河北石家庄052160 [3]大连理工大学化工学院精细化工系,辽宁大连116000 [4]北京大学医学部药学院天然药物化学系,北京100083

出　　处：《河北医科大学学报》2008年第1期66-70,共5页Journal of Hebei Medical University

摘　　要：目的研究丁苯酞等5个苯骈呋喃酮类化合物的质谱裂解特征。方法对于手性拆分的丁苯酞及丙苯酞采用质谱分析,丁烯苯酞的两个顺反异构体采用液相-质谱联用技术进行分离分析,并对5个苯骈呋喃酮类化合物的多级质谱裂解规律进行了详细解析。结果通过得到离子碎片的组成结构,可以进一步推断得出5个复杂的差向异构体或顺反异构体化合物形成碎片离子的裂解途径。结论该法简便、快速、准确,有助于对此类结构化合物更多的研究。Objective To find a mass spectrum characterization of benzofuranone compounds. Methods 3-n-propylphthalide,two epimers,and two cis-trans-isomers were analyzed under electrospray ionization tandem mass spectrometry （ESI-MS^n） or HPLC/MS conditions, respectively. A detailed analysis of benzofuranone compounds was also reported. Results Molecular composition data of the fragment ions were obtained with the aid of comparison of the multiple tandem mass spectra of five compounds. Attempts have been made to provide rational pathways for the formation of the fragment ions from these protonated compounds. Conclusion The method is quick, precise and simple. The mass spectrum data will provide useful knowledge for the identification of unknown relative compounds for which no synthetic and isolated reference compounds are available.

关 键 词：苯骈呋喃酮 光谱分析 质量 色谱法 高压液相 

分 类 号：R917[医药卫生—药物分析学]